Institute Introduction     Shenzhen University, Shenzhen University Institute for Advanced Study is a newly established comprising undergraduate and postgraduate training, focusing on interdisciplinary teaching and research of new school educational institutions. Shenzhen University Institute for Advanced Study is an exploration of a comprehensive internal reform and innovation, special management system, carry out cross-discipline innovation talent training and scientific research academic, DC, practice professor hospital treatment。

Hai Xiong

Ph.D, Research Scientist


Address: Room 352,Administration Building,Shenzhen University,3688 Avenue Nanhai, Nanshan District,Shenzhen, Guangdong, China, 518060


2006-2012  Ph.D

Osnabrück University, and Center for Nanotechnology (CeNTech) of Münster University, Germany.

2001-2004   Master

Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 

1997-2001 Bachelor

Nanchang University

Previous Positions/Employment

2012-2016   Postdoctoral Associate School of medicine, Yale University

2004-2006 Research Assistant Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Research Interests

Non-natural nucleic acids: Chemical modification and functionalization

DNA nucleobases

DNA fluorescence label

Fabrication of DNA self-assembled nanostructures

The property of DNA secondary structure: G-quadruplex and i-Motif

Synthesis of DNA/polymer hydrogel and its application

Synthesis of nano Medical and Biomaterials

The construction of 2D smart materials and non-natural nucleic acids: the application of biosensor and delivery of medicines

“Click”reaction induced the synthesis of cyclopeptides and its pharmacological research

Site-specific noncanonical amino acids and protein post-translational modification: lysine acetylation or methylation; phosphorylation of serine, threonine, tyrosine analogues


2017 High-Level Talents in Nanshan District of Shenzhen (Level C)

2016 Overseas High-Caliber Personnel (Peacock Plan, Level C)

Lab members:

Post doctor

Chandrasekar Selvaraj,doctor,Indian Institute of Technology-Madras

Selected Publications:

1) S. Chandrasekar and G.Sekar, Org. Biomol. Chem., 2016, 14, 3053.

2) S. Chandrasekar and G.Sekar, RSC. Advances 2015, 5, 58790.

Srinivas Bitta Thirumalavenkata,doctor,Indian Institute of Chemical Technology

Selected Publications:

1) B. T. V. Srinivas, et al., Advanced Synthesis and Catalysis, 2015, 357, 3587-3596.

2) B. T. V. Srinivas, et al., Advanced Synthesis and Catalysis, 2014, 356, 805-817.

3) B. T .V. Srinivas, et al., Tetrahedron, 2014, 70, 8161-8167.


Xuan Zhao,Chemistry,2018-2021


Haoran Xu, Chemistry,2015-2019

Han Cheng,Chemistry,2016-2020

Selected Publications:

H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme. Angew. Chem. Int. Ed. 2016, 55, 4083-4086.

C. Fan*, H. Xiong, N. Reynolds and D. Söll*, Rationally evolving tRNAPyl for efficient incorporation of noncanonical amino acids. Nucleic Acid Research. 2015, 43(22): e156

H. Xiong and F. Seela*, Cross-Linked DNA: Site Selective “Click” Ligation in Duplexes with Bis-Azides and Stability Changes Caused by Internal Cross-Links. Bioconjugate Chem., 2012, 23, 1230-1243.

H. Xiong, P. Leonard and F. Seela*, Construction and Assembly of Branched Y-shaped DNA: “Click” Chemistry Performed on Dendronized 8-Aza-7-deazaguanine Oligonucleotides. Bioconjugate Chem., 2012, 23, 856-870.

H. Xiong and F. Seela*, Stepwise “Click” Chemistry for the Template Independent Construction of a Broad Variety of Cross-linked Oligonucleotides: Influence of Linker Length, Position and Linking Number on DNA Duplex Stability. J. Org. Chem., 2011, 76, 5584-5597.

G. Qing, H. Xiong (Co-first authors), F. Seela*a and T. Sun*b, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites. J. Am. Chem. Soc., 2010, 132, 15228-15232.

F. Seela*, H. Xiong and S. Budow, Synthesis and “Double Click” Density Functionalization of 8-Aza-7-deazaguanine DNA Bearing Branched Side Chains with Terminal Triple Bonds. Tetrahedron, 2010, 66, 3930-3943.

F. Seela*, H. Xiong, P. Leonard and S. Budow, 8-Aza-7-deazaguanine Nucleosides and Oligonucleotides with Octadiynyl Side Chains: Synthesis, Functionalization by the Azide-Alkyne ‘Click’ Reaction and Nucleobase Specific Fluorescence Quenching of Coumarin Dye Conjugates. Org. Biomol. Chem., 2009, 7, 1374-1387.

Q. Yang, S. Ma*, J. Li, F. Xiao* and H. Xiong, A water-compatible, highly active and reusable PEG-coated mesoporous silica-supported palladium complex and its application in Suzuki coupling reactions. Chem. Commun., 2006, 2495-2497.

H. Xiong, F. Shi, J. Peng and Y. Deng*, Synthesis of supported gold catalysts for selective oxidation of cyclohexane with air. Chin. J. Mol. Catal., 2005, 19(3), 204-207.

H. Xiong, F. Shi and Y. Deng*, Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene. Chin. J. Catal., 2004, 25(11), 887-891.

F. Shi, H. Xiong, Y. Gu, S. Guo and Y. Deng*, The first non-acid catalytic synthesis of tert-butyl ether from tert-butyl alcohol using ionic liquid as dehydrator. Chem. Commun., 2003, 1054-1055.