Calcium Flickers Steer Cell Migration
Dr. Chaoliang Wei
Dept. of Cellular and Molecular Medicine, School of Medicine, Univ. of California
About the Speaker
Sep 1997 - Jul 2001 B.S., Dept. of Life Science, Peking University, Beijing, China.
Major: Physiology and Biophysics
Sep 2001 - Jul 2007 Ph.D., Dept. of Life Science& Institute of Molecular Medicine,
Peking University, Beijing, China.
Mar 2008 - Present Postdoctoral Fellow, Dept. of Cellular and Molecular Medicine,
School of Medicine, Univ. of California, San Diego.
Project: Splicing factors regulate cardiac function.
I caught a “hidden” calcium signal activity called “calcium flicker” which was most active at the leading lamella of migrating cells. When exposed to a PDGF gradient, asymmetric calcium flicker activity develops across the lamella and promotes the turning of migrating fibroblasts. The study not only resolved a long-standing paradox about calcium signaling in migrating cells, but also unmasked the underlying molecular basis, which might provide clues for developing new therapies for human diseases.
All are welcome！