高等研究院 Institute for Advanced Study
ZFP57 links maternal effect, genomic imprinting and NOTCH signaling
Dr. Li Xiajun, Ph.D.
About the speaker
Dr. Li was an excellent graduate of Peking University. He obtained PhD degree with distinction from Columbia University under supervision of Dr. Iva Greenwald, an HHMI investigator. His postdoctoral study was with Dr. Philip Leder, a senior HHMI investigator and the founding chair of Genetics Department in Harvard University.
Genomic imprinting is essential for mammalian development. Dysregulation of genomic imprinting is associated with many human diseases including cancer, diabetes, cardiovascular diseases and neurological disorders. My lab discovered ZFP57 as a master regulator of genomic imprinting. ZFP57 maintains DNA methylation imprint at many imprinted regions in mouse embryos and embryonic stem (ES) cells. Our results indicate that ZFP57, together with its cofactor KAP1/TRIM28, recruits DNA methyltransferases to the imprinting control regions. We found Zfp57 is a maternal-zygotic effect gene, the first one identified in mammals. Loss of just zygotic Zfp57 causes partial neonatal lethality, whereas elimination of both maternal and zygotic Zfp57 results in highly penetrant embryonic lethality around midgestation. Our recent results have demonstrated that both maternal and zygotic Zfp57 modulate Notch signaling in cardiac development. Thus, our studies on ZFP57 have provided the mechanistic links among maternal effect, genomic imprinting and NOTCH signaling in mammalian development.
时间: 2015年4月25日 上午09:30-10:30
All are welcome！