Designed New Strategies & Developed New Methodologies Towards the Synthesis of Biological Compounds
Dr. Wang Zhen, Ph.D.
About the speaker
Dr. Wang completed a B.S. degree in chemistry from LanZhou University in 2006. Zhen pursued his master at the Shanghai Institue of Organic Chemisty. In 2012, Zhen joined the Kanai laboratory at Tokyo University. His current research efforts focus on developing new methodologies for the synthesis of biological compounds.
Naturally occurring indole alkaloids exhibit interesting structural features and important biological activity, which attracts attentions from both chemists and biologists. Herein, I will talk the total synthesis of indole diterpenoids anominine and its natural congener tubingensin A using an advanced common intermediate based on a divergent strategy, to our knowledge, the synthesis of tubingensin A was accomplished for the first time. On the other hand, I designed new strategies and developed new methodologies towards the synthesis of biological compounds, such as duocarmycins family natural products, and ampiroxicam et al., these new methodologies contained the first copper catalyzed C(sp3) – H activation, first example of palladium catalyzed C(sp2) – H activation/coupling with a strained ring, and three new methodologies about sulfur compounds.
时间: 2015年4月12日 上午09:30-10:30
All are welcome！