Activation and Regulation of Innate Immune DNA-Sensing Pathways
Dr. Wang Pei-Hui
School of Biomedical Sciences, The University of Hong Kong
About the Speaker
Dr. Wang Pei-Hui was born in 1987, Anhui, China. He obtained B.Sc. & M.Sc. degrees in Biology from Sun Yat-Sen University (Sep. 2004-Jun. 2011). He got Ph.D. (Sep. 2011-Sep. 2015) in Biomedical Sciences and received post-doctoral training in innate antiviral immunity at the University of Hong Kong (Oct. 2015-present).
At Sun Yat-Sen University, he studied the antiviral immunity of Pacific white shrimp, an economically important marine invertebrate. For the first time, he demonstrated that invertebrates possess nucleic acid-induced non-specific antiviral immunity, and this antiviral response is a novel immune mechanism parallel to the mammalian interferon (IFN) system. Related results were published on Cell Mol Immunol and Antiviral Res. During his studies at the University of Hong Kong, he continued his research on immunology and reported two novel alternative transcripts of IFI16 and STING which play essential roles in the negative regulation of inflammasome activation and IFN production, respectively, during viral infections and the pathogenesis of autoimmune diseases. His findings propose that distinctive isoforms generated from alternative splicing/transcription represent another layer of immune regulators. Relevant results were published on EMBO Rep and Nucleic Acids Res.
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