学院简介

    深圳大学高等研究院是深圳大学新成立的一个包含本科与研究生培养、侧重跨学科教学与研究的校内综合办学单位。作为深圳大学内部探索全面改革创新的学术特区,高等研究院与香港和海外著名高校合作,借鉴国外研究型大学通行的管理模式,引进具有一流视野的资深教授和发展潜力的青年教师,营造与国际接轨的学术氛围和培养环境,开展卓越的教学、研究和管理工作。 ······

新闻动态

高等研究院系列学术讲座一百二十三

发布时间:2019-11-20 | 浏览次数:

To divide or not to divide?
Speaker Dr. Mingwei Min
Department of Biochemistry and Biofrontiers Institute, University of Colorado-Boulder 

 

About the Speaker
Dr. Min earned her PhD degree with Dr. Cath Lindon at the University of Cambridge. She moved across the pond to do a postdoc with Dr. Dan Finley at Harvard Medical School. She then joined Dr. Sabrina Spencer’s lab at University of Colorado-Boulder to understand how cells choose between proliferation and quiescence. 

 

Talk Introduction
Proper control of cellular proliferation and quiescence is fundamental to tissue homeostasis. My talk will center on two aspects of the control – how do cells interpret signals from fluctuating environments to make the proliferation-quiescence decision; and how do internal cell states influence the decision. Multi-cellular organisms use mitogens to regulate cell proliferation, yet how fluctuating mitogenic signals are converted into all-or-none proliferation-quiescence decisions is poorly understood. Here we combine live-cell imaging with temporally controlled perturbations to determine the timescale and mechanisms underlying the system. Contrary to the textbook model that cells only sense mitogen availability in G1, we find that mitogenic signaling is temporally integrated throughout the entire mother cell cycle, and that cells remember a one-hour lapse in MAPK signaling for over 12 hours. Therefore we identify a cellular memory-storage system that integrates mitogenic signals over long time periods to regulate proliferation rate. 

 

时间:2019年11月27日10:00-11:00
地点:汇元楼(原办公楼)103会议室
All are welcome!