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The Institute for Advanced Study (IAS) has been established at Shenzhen University to provide both undergraduate and postgraduate education, focusing on interdisciplinary teaching and research. As a special platform at Shenzhen University, IAS seeks to


An important research paper has published in "Organic Letters" by Hai Xiong group

Post Date:2020-12-19 | Counts:

Ming-Liang Han, Wei Huang, Yu-Wen Liu, Min Liu, Hui Xu*, Hai Xiong*, and Hui-Xiong Dai*

Herein a palladium-catalyzed ligandpromoted asymmetric dearomatization of indoles via the decarbonylation of thioesters and the subsequent reductive Heck reaction is reported. This protocol provides a facile and efficient way to construct an aza-quaternary stereocenter at the C2 position of indolines. A variety of functional groups and substitutions could be well tolerated, affording the substituted indolines with high enantioselectivities.