College Introduction

The Institute for Advanced Study (IAS) has been established at Shenzhen University to provide both undergraduate and postgraduate education, focusing on interdisciplinary teaching and research. As a special platform at Shenzhen University, IAS seeks to


Hai Xiong

Ph.D, Research Scientist


Address:   Room 352, Administration Building,Shenzhen University,3688 Avenue Nanhai, Nanshan District,Shenzhen, Guangdong, China, 518060


2006-2012  Ph.D  Osnabrück University, and Center for Nanotechnology (CeNTech) of Münster University, Germany.

2001-2004  Master  Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 

1997-2001  Bachelor  Nanchang University Previous Positions/Employment

2012-2016  Postdoctoral  Associate School of medicine, Yale University

2004-2006  Research  Assistant Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Research Interests

Non-natural nucleic acids:  Chemical modification and functionalization

DNA nucleobases

DNA fluorescence label

Fabrication of DNA self-assembled nanostructures

The property of DNA secondary structure: G-quadruplex and i-Motif

Synthesis of DNA/polymer hydrogel and its application

Synthesis of nano Medical and Biomaterials

The construction of 2D smart materials and non-natural nucleic acids:  the application of biosensor and delivery of medicines

“Click”reaction induced the synthesis of cyclopeptides and its pharmacological research

Site-specific noncanonical amino acids and protein post-translational modification: lysine acetylation or methylation; phosphorylation of serine, threonine, tyrosine analogues


2018   Pearl River plan-young Talents in Guangdong province

2017   High-Level Talents in Nanshan District of Shenzhen

2016   Overseas High-Caliber Personnel (Peacock Plan)

Academic service:

Chinese Chemical Letters:  Young Editorial Members

Frontiers in Bioengineering and Biotechnology:  Lead Guest Editor

Lab members:

Current Post doctor

2019-2022 Farid Ahmed, 超分子化学,巴基斯坦卡拉奇大学(Karachi University)

2021-2023 Jabrane Jouha,有机化学,法国奥尔良大学(University of Orléans)

2021-2023 裴海翔,生物化学与分子生物学,华东师范大学

2021-2023 Waheed Ullah Khan, 材料物理与化学, 兰州大学

2022-2024 Muhammad Muzammal Hussain, 大连理工大学

2022-2024 金旺锐,生物化学与分子生物学,华东师范大学

Alumni (Post doctor)

2018-2020 Chandrasekar Selvaraj,有机化学,印度理工学院Madras分校(Indian Institute of Technology,Madras)

2018-2021 Srinivas Bitta Thirumalavenkata,有机化学,印度化学技术研究所(Indian Institute of Chemical Technology, Hyderabad)

2018-2020 肖秋芸,微生物,华中科技大学

2019-2021 韩明亮,有机化学,南开大学

2019-2021 赵龙,有机化学,德国亚琛工业大学(RWTH Aachen University)

2020-2022 Shahzad Iqbal,核酸化学,四川大学















Publications (2016-now),*corresponding author

18. Muhammad Muzammal Hussain, Waheed Ullah Khan, Farid Ahmed, and Hai Xiong*, Recent developments of Red/NIR-CDs in biosensing, bioimaging, and tumor theranostics. 2022, submitted.

17. Weiqing Xu, Farid Ahmed, and Hai Xiong*, A mitochondria-targeted fluorescent probe based on biocompatible RBH-U for the enhanced response of Fe3+ in living cells and quenching of Cu2+ in vitro. 2022, submitted.

16. Xue-Yan Yang, Bo Yuan, Hai Xiong*, Yahao Zhao, Lu Wang, San-Qi Zhang,* and Shuai Mao*, Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs. Bioorganic Chemistry 2022, 129, 106154.

15. Long Zhao, Farid Ahmed, Yating Zeng, Weiqing Xu, and Hai Xiong*. Recent Developments in G‑Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes. ACS Sensors 2022, DOI: 10.1021/acssensors.2c00992

14. Farid Ahmed, Shahzad Iqbal, and Hai Xiong*, Multifunctional Dual Emissive Fluorescent Probe Based on Europium-doped Carbon Dots (Eu-TCA/NCDs) for Highly Selective Detection of Chloramphenicol, Hg2+ and Fe3+. Environmental Science-Nano 2022, online(封面文章)

13. Jabrane Jouha, Fengli Li, Wen-Ta Su*, Chenguang Fan*, Dayong Yang*, and Hai Xiong*, Editoral: Engineering Nucleic Acids-based Functional Nanomaterials, Nanodrugs, and Biosensors. Frontiers in Bioengineering and Biotechnology 2022, 10, 915229.

12. Shahzad Iqbal, Farid Ahmed, Ziyan Wang, Weiqing Xu, Yating Zeng, and Hai Xiong*. Multi-stimuli Responsive Poly(N-isopropyl-co-tetraphenylethene) acrylamide Copolymer Mediating AIEgens by Controllable Tannic Acid. Polymer 2022, 249, 124824.

11. Haixiang Pei, Weikai Guo, Yangrui Peng, Hai Xiong, and Yihua Chen*. Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective. Med Res Rev. 2022, 42, 1607–1660.

10. Long Zhao, Farid Ahmed, and Hai Xiong*, An excimer ‘ON –OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection. Chinese Chemical Letters 2022, 33, 4243–4247.

9. Jabrane Jouha, and Hai Xiong*, DNAzyme-Functionalized nanomaterials: Recent Preparation, Current Applications, and Future Challenges. Small 2021, 2105439. (封面文章)

8. Farid Ahmed, Shahzad Iqbal, Long Zhao, and Hai Xiong*, “ON-OFF-ON” fluorescence switches based on N,S-doped carbon dots: Facile hydrothermal growth, selective detection of Hg2+, and as a reversive probe for guanine. Analytica Chimica Acta 2021, 1183, 338977.

7. Shahzad Iqbal, Farid Ahmed, and Hai Xiong*, Responsive-DNA hydrogel based intelligent materials:  Preparation and applications. Chemical Engineering Journal 2021, 420, 130384.

6. Qiuyun Xiao, Xuan Zhao, and Hai Xiong*, Biocompatible and noncytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids. Chinese Chemical Letters 2021, 32, 1687–1690. (封面文章)

5. Ming-Liang Han, Wei Huang, Yu-Wen Liu, Min Liu, Hui Xu*, Hai Xiong*, and Hui-Xiong Dai*, Pd-Catalyzed Asymmetric Dearomatization of Indoles via Decarbonylative Heck-Type Reaction of Thioesters. Organic Letters 2021, 23, 172−177.

4. Xuan Zhao, Long Zhao, Qiuyun Xiao, and Hai Xiong*, Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels. Chinese Chemical Letters 2021, 32, 1363–1366.

3. Farid Ahmed, and Hai Xiong*, Recent developments in 1,2,3-triazole-based chemosensors. Dyes and Pigments 2021, 185, 108905.

2. Farid Ahmed, Humaira Kabir, and Hai Xiong*, Dual Colorimetric Sensor for Hg2+/Pb2+ and an Efficient Catalyst Based on Silver Nanoparticles Mediating by the Root Extract of Bistorta Amplexicaulis. Frontiers in Chemistry 2020, 8, 591958.

1. Qiuyun Xiao, Zihan Liu, Xuan Zhao, and Hai Xiong*, Multiple Site-specific One-Pot Synthesis of Two Proteins by the Bio-orthogonal Flexizyme System. Frontiers in Bioengineering and Biotechnology 2020, 8, 37.


SPRINGER NATURE:  Book entitled “Metal, Metal-Oxides and Metal Sulfides for Batteries, Fuel Cells, Solar Cells, Photocatalysis and Health Sensors” 2021, ISBN 978-3-030-63791-0 (eBook)

Chapter 8: Developing Trends in DNA Biosensor and Their Applications ---Chandrasekar Selvaraj, Srinivas Bitta Thirumalavenkata and Hai Xiong*---

Selected Publications(2004-2016)

H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme. Angew. Chem. Int. Ed. 2016, 55, 4083-4086.

C. Fan*, H. Xiong, N. Reynolds and D. Söll*, Rationally evolving tRNAPyl for efficient incorporation of noncanonical amino acids. Nucleic Acid Research. 2015, 43(22): e156

H. Xiong and F. Seela*, Cross-Linked DNA: Site Selective “Click” Ligation in Duplexes with Bis-Azides and Stability Changes Caused by Internal Cross-Links. Bioconjugate Chem., 2012, 23, 1230-1243.

H. Xiong, P. Leonard and F. Seela*, Construction and Assembly of Branched Y-shaped DNA: “Click” Chemistry Performed on Dendronized 8-Aza-7-deazaguanine. Oligonucleotides. Bioconjugate Chem., 2012, 23, 856-870.

H. Xiong and F. Seela*, Stepwise “Click” Chemistry for the Template Independent Construction of a Broad Variety of Cross-linked Oligonucleotides: Influence of Linker Length, Position and Linking Number on DNA Duplex Stability. J. Org. Chem., 2011, 76, 5584-5597.

G. Qing, H. Xiong (Co-first authors), F. Seela* and T. Sun*, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites. J. Am. Chem. Soc., 2010, 132, 15228-15232.

H. Xiong, F. Shi, J. Peng and Y. Deng*, Synthesis of supported gold catalysts for selective oxidation of cyclohexane with air. Chin. J. Mol. Catal., 2005, 19(3), 204-207.

H. Xiong, F. Shi and Y. Deng*, Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene. Chin. J. Catal., 2004, 25(11), 887-891.