College Introduction

The Institute for Advanced Study (IAS) has been established at Shenzhen University to provide both undergraduate and postgraduate education, focusing on interdisciplinary teaching and research. As a special platform at Shenzhen University, IAS seeks to

Postgraduate Course

Hai Xiong

Hai Xiong

Ph.D, Research Scientist

E-mail:  hai.xiong@szu.edu.cn

Address:   Room 352, Administration Building,

Shenzhen University,3688 Avenue Nanhai, Nanshan District,Shenzhen, Guangdong, China, 518060


Eductation

2006-2012    Ph.D

Osnabrück University, and Center for Nanotechnology (CeNTech) of Münster University, Germany.

2001-2004    Master

Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 

1997-2001     Bachelor

Nanchang University


Previous Positions/Employment

2012-2016    Postdoctoral Associate

School of medicine, Yale University

2004-2006     Research Assistant

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences


Research Interests

Non-natural nucleic acids:  Chemical modification and functionalization

DNA nucleobases

DNA fluorescence label

Fabrication of DNA self-assembled nanostructures

The property of DNA secondary structure: G-quadruplex and i-Motif

Synthesis of DNA/polymer hydrogel and its application

Synthesis of nano Medical and Biomaterials

The construction of 2D smart materials and non-natural nucleic acids:  the application of biosensor and delivery of medicines

“Click”reaction induced the synthesis of cyclopeptides and its pharmacological research

Site-specific noncanonical amino acids and protein post-translational modification: lysine acetylation or methylation; phosphorylation of serine, threonine, tyrosine analogues


Honor:

2018   Pearl River plan-young Talents in Guangdong province

2017   High-Level Talents in Nanshan District of Shenzhen

2016   Overseas High-Caliber Personnel (Peacock Plan)


Academic service:

Chinese Chemical Letters:  Young Editorial Members

Frontiers in Bioengineering and Biotechnology:  Lead Guest Editor


Lab members:

Current Post doctor

Farid Ahmed, Supermolecular chemistry, Karachi University (Pakistan)

Shahzad Iqbal, Nucleic Acid Chemistry, Sichuang University

Jabrane Jouha, Organic chemistry, University of Orléans (France)

裴海翔,Biochemistry and molecular biology, East China Normal University

Waheed Ullah Khan, Materials Physics and Chemistry, Lanzhou University

Muhammad Adnan Bashi, Organic chemistry, Huazhong University of Science and Technology


Alumni (Post doctor)

Chandrasekar Selvaraj, Organic chemistry,Indian Institute of Technology-Madras (India)

Srinivas Bitta Thirumalavenkata, Organic chemistry, Indian Institute of Chemical Technology (India)

肖秋芸, Microbilogy, Huazhong University of Science and Technology

韩明亮, Organic chemistry, Nankai University

赵龙, Organic chemistry,RWTH Aachen University (Germany)


Graduate

赵烜, Chemistry, 2018-2021

曾雅婷, Biology, 2021-2024

徐伟清, Biology, 2021-2024


Undergraduate

赵烜,2014-2018

徐浩然,2015-2019

刘姿含,2016-2020

杨鑫晨,2016-2020

陈瀚,2016-2020


Publications (2016-now),*corresponding author

9. Farid Ahmed, Shahzad Iqbal, Long Zhao and Hai Xiong*. N, S-doped carbon dots-based reversible fluorescence switch for selective discrimination of Hg2+ and guanine at independent pH. 2021, Submitted

8. Long Zhao, Farid Ahmed and Hai Xiong*. Reduced graphene oxide and G-quadruplex DNA nanointerface-based bioconjugatable multi-pyrene excimer emission for amplified thrombin detection. 2021, Submitted

7. Shahzad Iqbal, Farid Ahmed and Hai Xiong*. Responsive-DNA hydrogel based intelligent materials:  Preparation and applications. Chemical Engineering Journal 2021, 420, 130384.

6. Qiuyun Xiao, Xuan Zhao and Hai Xiong*. Biocompatible and noncytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids. Chinese Chemical Letters 2021, 32, 1687–1690 (Cover paper)

5. Ming-Liang Han, Wei Huang, Yu-Wen Liu, Min Liu, Hui Xu*, Hai Xiong*, and Hui-Xiong Dai*. Pd-Catalyzed Asymmetric Dearomatization of Indoles via 2 Decarbonylative Heck-Type Reaction of Thioesters. Organic Letters 2021, 23, 172−177.

4. Xuan Zhao, Long Zhao, Qiuyun Xiao and Hai Xiong*, Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels. Chinese Chemical Letters 2021, 32, 1363–1366.

3. Farid Ahmed and Hai Xiong*, Recent developments in 1,2,3-triazole-based chemosensors. Dyes and Pigments 2021, 185, 108905.

2. Farid Ahmed, Humaira Kabir and Hai Xiong*, Dual Colorimetric Sensor for Hg2+/Pb2+ and an Efficient Catalyst Based on Silver Nanoparticles Mediating by the Root Extract of Bistorta Amplexicaulis. Frontiers in Chemistry 2020, 8, 591958.

1. Qiuyun Xiao, Zihan Liu, Xuan Zhao and Hai Xiong*, Multiple Site-specific One-Pot Synthesis of Two Proteins by the Bio-orthogonal Flexizyme System. Frontiers in Bioengineering and Biotechnology 2020, 8, 37.


Book-Chapter

SPRINGER NATURE:  Book entitled “Metal, Metal-Oxides and Metal Sulfides for Batteries, Fuel Cells, Solar Cells, Photocatalysis and Health Sensors” 2021, ISBN 978-3-030-63791-0 (eBook)

Chapter 8: Developing Trends in DNA Biosensor and Their Applications ---Chandrasekar Selvaraj, Srinivas Bitta Thirumalavenkata and Hai Xiong*---


Selected Publications(2004-2016)

H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme. Angew. Chem. Int. Ed. 2016, 55, 4083-4086.

C. Fan*, H. Xiong, N. Reynolds and D. Söll*, Rationally evolving tRNAPyl for efficient incorporation of noncanonical amino acids. Nucleic Acid Research. 2015, 43(22): e156

H. Xiong and F. Seela*, Cross-Linked DNA: Site Selective “Click” Ligation in Duplexes with Bis-Azides and Stability Changes Caused by Internal Cross-Links. Bioconjugate Chem., 2012, 23, 1230-1243.

H. Xiong, P. Leonard and F. Seela*, Construction and Assembly of Branched Y-shaped DNA: “Click” Chemistry Performed on Dendronized 8-Aza-7-deazaguanine. Oligonucleotides. Bioconjugate Chem., 2012, 23, 856-870.

H. Xiong and F. Seela*, Stepwise “Click” Chemistry for the Template Independent Construction of a Broad Variety of Cross-linked Oligonucleotides: Influence of Linker Length, Position and Linking Number on DNA Duplex Stability. J. Org. Chem., 2011, 76, 5584-5597.

G. Qing, H. Xiong (Co-first authors), F. Seela*a and T. Sun*b, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites. J. Am. Chem. Soc., 2010, 132, 15228-15232.

H. Xiong, F. Shi, J. Peng and Y. Deng*, Synthesis of supported gold catalysts for selective oxidation of cyclohexane with air. Chin. J. Mol. Catal., 2005, 19(3), 204-207.

H. Xiong, F. Shi and Y. Deng*, Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene. Chin. J. Catal., 2004, 25(11), 887-891.