Ph.D., Principle Investigator, Assistant Professor
Address: Room 313, Administration building, Houhai Campus, Shenzhen University
2009, Institute of Chemistry Chinese Academy of Sciences, Chemistry, Ph.D
2004, Tsinghua University，Chemistry, Bachelor
2016.7 - present, Shenzhen University, Institute for Advanced Study, Principle Investigator, Assistant Professor
2016.1 - 2016.6, Institute of Chemistry Chinese Academy of Sciences, Associate Research Fellow
2015.1 - 2016.5, The State University of New York at Stony Brook, Chemistry, visiting scholar
2009.7 - 2016.1, Institute of Chemistry Chinese Academy of Sciences, Assistant Research Fellow
2019.2- present, University of Maryland, College Park，Materials science and engineering, Adjunct associate professor
American Physical Society, member
2016 Shenzhen Overseas High-Caliber Personnel (Level C)
2018 High-Level Talent in Nanshan District of Shenzhen
2018 Guangdong College Students' entrepreneurship Competition in 2018, Bronze award, Advisor
1. Design, development and performance evaluation of high-performance implant medical devices
(1) Application of polymer materials in the field of surgical repair
Currently, the absorbable surgical implant materials are absorbable polymer (fatty group polyester), mainly including PLA (polylactic acid), PGA (polyglycolic acid) and their copolymers (PDLLA and PLGA).They have good biocompatibility, adjustable mechanical properties, degradation and absorptivity, and can be made into medical implants for abdominal and orthopedic surgery. Bioabsorbable grafts have a number of potential advantages over traditional metal implants, like avoiding image hiding, reducing the chance of infection and so on. These polymer materials can be widely used in the clinical application of hemostasis and adhesion prevention, nerve repair, etc., and have a broad commercial prospect. This research group is committed to developing absorbable surgical implant materials with clinical application prospect.
(2) The design and development of multi-level controlled-release system, the attempt of application and the study of controlled-release mechanism
In view of tumor resection, the fiber membrane loaded with gold nanorods and chemotherapy drugs can be implanted in situ to prevent tumor metastasis. The chemotherapy drugs can be released in situ to kill the tumor cells. Accurate control of the loading dose and release rate can greatly improve the drug utilization rate, reduce systemic toxic and side effects, and improve the survival rate. As an excellent drug carrier, the drug release curve of electrospun fibrous membrane has been widely studied. Through a variety of drug and polymer models, this project aims to control the interaction between the polymer and the drug, the swelling behavior of the second component, the degradation time of the polymer and the dissolution behavior of the oligomer, so as to accurately regulate the release cycle and dose of the drug and to effectively solve the clinical needs.
(3) Study on the interaction between implanted polymer material and biological matrix
The design and development of medical devices using new raw materials or imperfect risk assessment can easily bring huge risks to patients. For example, absorbable suture or absorbable bone nails may cause material strength to decrease and wound cracking in advance due to the loose control of water content in the storage process. The PU coating of cardiac pacemaker is broken due to the aging behavior of long-term implantation. As a result, the power cord of the pacemaker is exposed, the pacemaker is not working normally and even threatens the patient's life eventually. As a hernia patch, the expanded PTFE repair membrane is vulnerable to cause late infection because the pores can harbor bacteria but cannot allow macrophages to pass through. It is relatively easy to select new polymer materials in terms of performance. However, due to the lack of clinical use history, there are many unknown risks in their degradation and in vivo metabolism. This project is dedicated to the selection of polymer raw materials with many years of clinical use experience. A series of products for clinical indications were developed only through structural design and regulatory performance design, and the biological mechanism of action will be studied in depth.
(4) Design, development and application of artificial mesh/blood vessel
A hernia is a condition in which a tissue or organ moves out of its normal position and through a weak or defective part into another position. Since Lichtenstein proposed tension-free hernia mesh prosthetics, traditional tension-free prosthetics have been gradually replaced. There are four common hernia mesh materials: autograft/allograft, heterograft, synthetic, and composite. Among them, synthetic materials have many kinds of raw materials, simple preparation process and good biocompatibility, which have become the hot materials for the preparation of hernia mesh. The hernia mesh has different forms in different operations. For abdominal wall hernia, the use of light mesh mesh hernia mesh; To better protect the spinal cord or brain when repairing the dural, a dense, membranous patch is used. Based on electrospinning technology and bio-inert polymer materials, this project is dedicated to the preparation of thin-film dural mesh and the large-scale and high-quality production of the mesh.
2. Study on phase structure, crystal form and material properties
(1) Phase separation, crystallization and morphology of blended polymers
As the most widely used plastic material in the 21st century, polyolefin can form special phase morphology and structure in the processing process, and thus obtain special properties, which has become a hot research system of condensed matter theory. In this study, HDPE/ CFC-11 blends were selected to study the control of phase separation, crystallization, morphology and performance under dynamic symmetry and asymmetry.
(2) Study on phase separation kinetics, crystallization kinetics and morphology of polymer under high temperature and high pressure
Flash spinning is a process in which a polymer solution is dissolved in a special spinning solvent and sprayed out at high pressure to produce extremely fine fibers. The blend solution reached a homogeneous state under high temperature and pressure, and was finally ejected through the nozzle. The pressure decreased rapidly, the spinning solvent evaporated rapidly, and the polymer chain crystallized and was rapidly stretched into fine fibers due to the supersonic flow. Flash spinning generally has strong mechanical properties and good waterproof and breathable property, which is mostly used in protective clothing and medical clothing industry. This project is devoted to controlling the morphology and properties of the final produced fiber by means of flash spinning to control the homogeneous state when the fiber is ejected, and studying the kinetics of phase separation and crystallization of the polymer under high temperature and pressure.
1. Shenzhen high-end talent scientific research project, Design and development of implant devices and their preclinical evaluation, from 2018-01 to 2020-12，￥3000,000, under study, leader.
2. Basic research project of knowledge innovation plan of Shenzhen, Study on drug-loaded fibrous membranes used for postoperative chemotherapy of tumors, from 2017-08 to 2020-03, ￥490,000, under study, leader.
3. Youth Program of National Natural Science Foundation of China, Study on anti - adhesion and anti - infection functionalization of microfiber membrane, from 2012-01to 2013-12，￥250,000, finished, leader.
4. Important direction project of knowledge innovation project of Chinese Academy of Sciences, Study on the key physical and chemical problems of macromolecule in biomedical and environmental water treatment applications, from 2009-09 to 2013-09，￥600,000，finished, participated.
5. Youth Program of National Natural Science Foundation of China, Preparing hyaluronic acid (HA) based nanofibrous membrane by electrospinning, from 2006-01 to 2008-12, ￥250,000, finished, participated.
1. Jiaen Wu#, Zixin Zhang#, Jin’ge Gu#, Weixian Zhou, Xiaoyu Liang, Guoqiang Zhou, Charles C. Han, Shanshan Xu*, Ying Liu*; Mechanism of a Long-Term Controlled Drug Release System Based on Simple Blended Electrospun Fibers, Journal of Controlled Release (2020), 320: 337-346.
2. Qinghua Xia#, Nuozi Zhang#, Jiangxue Li#, Heran Wang, Chenhong Wang, Zixin Zhang, Jin’ge Gu, Mengjie Wang, Charles C. Han, Shanshan Xu*, Ying Liu*; Dual-Functional Esophageal Stent Coating Composed of Paclitaxel-Loaded Electrospun Membrane and Protective Film, Journal of Biomedical Nanotechnology (2019), 15(10): 2108-2120.
3. Zhu, Xin-Xing & Yan, Ya-Wei & Ai, Chun-Zhi & Jiang, Shan & Xu, Shan-Shan & Niu, Min & Wang, Xiang-Zhen & Zhong, Gen-Shen & Lu, Xifeng & Xue, Yu & Tian, Shaoqi & Li, Guangyao & Tang, Shaojun & Jiang, Yi-Zhou. Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. Oncotarget(2017), 8(15).
4. Chen, Demeng & Zhu, Xin-Xing & Yan, Ya-Wei & Ai, Chun-Zhi & Lu, Xifeng & Xu, Shan-Shan & Jiang, Shan & Zhong, Genshen & Chen, Dong-Bao & Jiang, Yi-Zhou. Long Non-coding RNA HoxA-AS3 interacts with EZH2 to Regulate Lineage Commitment of Mesenchymal Stem Cells. Oncotarget (2016), 7(39).
5. Zixin Zhang, Jianxiong Tang, Heran Wang, Qinghua Xia, Shanshan Xu*, Charles Han*. Controlled Antibiotics Release System through Simple Blended Electrospun Fibers for Sustained Antibacterial Effects. ACS Applied Materials & Interfaces (2015), 7, 26400−26404.
6. Qinghua Xia, Ziwen Liu, Chenhong Wang, Zixin Zhang, Shanshan Xu*, and Charles C. Han* A Biodegradable trilayered barrier membrane composed of sponge and electrospun layers: hemostasis and antiadhesion. Biomacromolecules (2015), 16, 3083-3092.
7. Chenhong Wang, Kuo Zhang, Heran Wang, Shanshan Xu*, Charles C. Han*, Evaluation of biodegradability of poly (DL-lactic -co-glycolic acid) scaffolds for post-surgical adhesion prevention: In vitro, in rats and in pigs. Polymer (2015), 61, 174-182.
8. Ming Cheng, Heran Wang, Zhen Zhang, Nan Li, Xiaohong Fang*, Shanshan Xu*, Gold nanorod-embedded electrospun fibrous membrane as a photothermal therapy platform. ACS Applied Materials & Interfaces (2014), 6 (3), 1569–1575.
9. Heran Wang, Ming Cheng, Jianming Hu, Chenhong Wang, Shanshan Xu* and Charles C Han*. “Preparation and Optimization of Silver Nanoparticles Embedded Electrospun Membrane for Implant Associated Infections Prevention.” ACS Applied Materials & Interfaces (2013), 5 (21), 11014–11021.
10. Heran Wang, Min Li, Jianming Hu, Chenhong Wang, Shanshan Xu*, Charles C. Han*. Multiple Targeted Drugs Carrying Biodegradable Membrane Barrier: Anti-Adhesion, Hemostasis and Anti-Infection. Biomacromolecules (2013) 14: 954-961.
11. Shanshan Xu, Junxing Li, Aihua He*, Wenwen Liu, Xingyu Jiang, Jianfen Zheng, Charles C. Han*, Dufei Fang, Benjamin S. Hsiao, Benjamin Chu. Chemical crosslinking and biophysical properties of the electrospun hyaluronic acid based ultra-thin fibrous membranes. Polymer (2009) 50: 3762-3769.
12. Shanshan Xu, Jun Zhang, Aihua He*, Junxing Li, Hao Zhang, Charles C. Han*. Electrospinning of native cellulose from nonvolatile solvent system, Polymer (2008) 49: 2911–2917.
13. Huarong Nie, Aihua He*, Jianfen Zheng, Shanshan Xu, Junxing Li, Charles C. Han*. Effects of chain conformation and entanglement on the electrospinning of pure alginate."Biomacromolecules (2008) 9: 1362-1365.
14. HuarongNie, Aihua He*, jianfenzheng, Shanshan Xu, Charles C Han*. The effect of PEO on the electrospinnability of sodium alginate from its aqueous solution.Polymer (2009) 50：4926-4934.
15. HuarongNie, Junxing Li, Aihua He*, Shanshan Xu, Qingsong Jiang, Charles C Han*. Carrier system of chemical drugs and isotope from gelatin electrospun nanofibrous membranes. Biomacromolecules (2010) 11: 2190-2194.
16. Hongchao Zheng, Changmei Chen*, Hua Wang, Shanshan Xu, Yufen Zhao. Study on disulfur-backboned nucleic acid: part 1, efficient synthesis of 3 ',5 '-dithio-2 '-deoxyadenosine. Synlett (2004) 14: 2585-2587.
17. Hua Wang, Changmei Cheng*, Hongchao Zheng, Xiaohong Liu, Chang Fang, Shanshan Xu, Yufen Zhao. Study on disulfur-backboned nucleic acid: part 2, efficient synthesis of 3 ,5 -dithiothymidine. Chemistry Letters (2005) 36: 34-266.
31 authorized national invention patents and 3 authorized patents for utility models; over 60 patents under substantive examination;
CN201310586339.X; CN201210444940.0; CN201310586082.8; CN201310594072.9; 201811377100 .0; CN201110347250.9; CN201310594218.X; CN201120205760.8…
Conferences and Presentations:
2017.11, International Symposium on polymer and condensed matter physics, Shenzhen, Organizers
2018.03, The APS March Meeting, Los Angeles, Invited talk: Physical or Chemical Aging of PLGA Electrospun Fibers Related to its Sequence Distribution