学院简介

深圳大学高等研究院是深圳大学于2014年成立的一个包含本科与研究生培养、侧重跨学科教学与学术研究的校内综合办学单位。作为深圳大学内部探索全面改革创新的学术特区,高等研究院与香港和海外著名高校合作,借鉴国内外研究型大学通行的管理模式,引进具有一流视野的资深教授和发展潜力的青年教师,营造与国际接轨的学术氛围和培养环境,开展卓越的教学、研究和管理工作。

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Nidhi Singh(Wenjin Li's group)

 

Postdoc fellow

Email: tanwar.nidhi7@gmail.com

Address:Room 713, institute of advanced study, Shenzhen University, Nanhai Avenue 3688, Nanshan District, 518060 Shenzhen, China


 

EDUCATION

2012-2017 Doctorate of Philosophy, Bioinformatics CSIR-Central Drug Research Institute, Lucknow, India

2007-2009 Master of Science, Bioinformatics CCS- HAU, Hisar, India


 

RESEARCH INTERESTS

Informatics: Bio-informatics, Chem-informatics and Pharmaco-informatics

Computational Structural Biology: Biomolecular engineering & Modeling, Computer-Aided Molecular Design and Simulation, Quantum Chemical Calculations.

Rational Drug Design: Virtual screening, de novo design, pharmacophore perception, SAR and ADME, Molecular docking, Conformational Analysis, Binding free energy simulations, Protein Ligand interactions etc.

Evolutionary Bioinformatics: Phylogenetic Analysis etc.


 

Selected Publications:

1. Singh, N.; Tiwari, S.; Srivastava, K. K.; Siddiqi, M. I., Identification of Novel Inhibitors of Mycobacterium tuberculosis PknG Using Pharmacophore Based Virtual Screening, Docking, Molecular Dynamics Simulation, and Their Biological Evaluation. J Chem Inf Model 2015, 55 (6), 1120-9

2. Singh, N.; Shah, P.; Dwivedi, H.; Mishra, S.; Tripathi, R.; Sahasrabuddhe, A. A.; Siddiqi, M. I., Integrated machine learning, molecular docking and 3D-QSAR based approach for identification of potential inhibitors of trypanosomal N-myristoyltransferase. Mol Biosyst 2016, 12 (12), 3711-3723

3. Charan, M.; Singh, N.; Kumar, B.; Srivastava, K.; Siddiqi, M. I.; Habib, S., Sulfur mobilization for Fe-S cluster assembly by the essential SUF pathway in the Plasmodium falciparum apicoplast and its inhibition. Antimicrob Agents Chemother 2014, 58 (6), 3389-98

4. Mishra AK, Singh N, Agnihotri P, Mishra S, Singh SP, Kolli BK, Chang KP, Sahasrabuddhe AA, Siddiqi MI, Pratap JV. Discovery of novel inhibitors for Leishmania nucleoside diphosphatase kinase (NDK) based on its structural and functional characterization. J Comput Aided Mol Des. 2017 Jun;31(6):547-562.

5.Singh N., Siddiqi M.I., Computational evaluation of Glutamine Synthetase as Drug Target against Infectious Diseases: Molecular Modelling, Substrate Binding Analysis and Molecular Dynamics Simulation Studies. Med chem res, 2017, DOI: 10.1007/s00044-016-1766-9

6.Nidhi; Siddiqi, M. I., Recent advances in QSAR-based identification and design of anti-tubercular agents. Curr Pharm Des 2014, 20 (27), 4418-26