学院简介

深圳大学高等研究院是深圳大学于2014年成立的一个包含本科与研究生培养、侧重跨学科教学与学术研究的校内综合办学单位。作为深圳大学内部探索全面改革创新的学术特区,高等研究院与香港和海外著名高校合作,借鉴国内外研究型大学通行的管理模式,引进具有一流视野的资深教授和发展潜力的青年教师,营造与国际接轨的学术氛围和培养环境,开展卓越的教学、研究和管理工作。

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Chunling Ai(Yizhou Jiang's group)

Ph.D

E-mail: angelina_ai@163.com


 

EDUCATION&RESEARCH:

2017.1- present Postdoc, Institute of Advaced Study, Shenzhen University

2012.12- 2015.9 Faculty, Associate ProfessorDalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP), DALIAN City, P. R. CHINA

2010.6-2012.12 Faculty, Assistant Professor Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP), DALIAN City, P. R. CHINA

2006.7–2010.3 Ph.D. Biochemical Engineering,Dalian Institute of Chemical Physics, Chinese Academy of Sciences (DICP), Dalian City, P. R. CHINA

2003.7-2006.7 M.S. Physical chemistry,Liaoning Normal University (LNU), DALIAN City, P. R. CHINA

1997.7-2001.7 B.S. Chemistry,Bohai University, Jinzhou City, P. R. CHINA Research interest: Bioinformatics, Drug Discovery, Pharmacokinetics


 

PUBLICATIONS:

Zhu X, Yan Y, Ai C, Jiang S, Xu S, Niu M, Wang X, Zhong G, Lu X, Xue Y, Tian S, Li G, Tang S, Jiang YZ. Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. Oncotarget. 2017 Apr 11;8(15):24483-24490.

Zhu X, Yan Y, Chen D, Ai C, Lu X, Xu S, Jiang S, Zhong G, Chen D, Jiang Y. Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2016;7(39):63561-63570.

Wang Y, Wu M, Ai C, Wang Y.Insight into the Structural Determinants of Imidazole Scaffold-Based Derivatives as TNF-α Release Inhibitors by in Silico Explorations. Int J Mol Sci. 2015;16(9):20118-38.

Dai Z1, Ai C1, Ge G, He Y, Wu J, Wang J, Man H, Jia Y and Yang L. A Mechanism-Based Model for the Prediction of the Metabolic Sites of Steroids Mediated by Cytochrome P450 3A4. Int. J. Mol. Sci. 2015, 16, 14677-14694.(1 Co-first author)

Gao X, Qu H, Ai C, Cao Y, Huang T, Chen J, Zeng J, Sun X, Hong M, Gonzalez F, Liu Z, Fang Z. Xenobiotica. Regulation profile of phosphatidylcholines (PCs) and lysophosphatidylcholines (LPCs) components towards UDP-glucuronosyltransferases (UGTs) isoforms. Xenobiotica.2015;45(3):197-206.

Ma H, Sun D, Cao Y, Ai C, Qu Y, Hu C, Jiang C, Dong P, Sun X, Hong M, Tanaka N, Gonzalez F, Ma X, Fang Z. Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7. Toxicol Appl Pharmacol. 2014; 277(1):86-94.

Li Y, Han C, Wang J, Xiao W, Wang Z, Zhang J, Yang Y, Zhang S, Ai C. Investigation into the mechanism of Eucommia ulmoides Oliv. based on a systems pharmacology approach. J Ethnopharmacol. 2014,151(1), 452-460.

Ge G1, Ai C1, Hu W, Hou J, Zhu L, He G, Fang Z, Liang S, Wang F, Yang L. The role of serum albumin in the metabolism of Boc5: molecular identification, species differences and contribution to plasma metabolism. Eur J Pharm Sci. 2013 23; 48(1-2):360-9.(1 Co-first author)

Ge G, Ning J, Hu L, Dai Z, Hou J, Cao Y, Yu Z, Ai C, Gu J, Ma X, Yang L. A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications. Chem Commun. 2013; 49 ( 84): 9779-9781.

Fang Z, He, R,Cao, Y, Tanaka N, Jiang C, Krausz K, Qi Y, Dong P, Ai C, Sun X, Hong M, Ge G; Gonzalez F, Ma X, Sun H. A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders. J Lipid Res. 2013; 54(12): 3334-3344.

Zhou K, Ai C, Dong P, Fan X, Yang L. A novel model to predict O-glycosylation sites using a highly unbalanced dataset. Glycoconj J. 2012. 29 (7): 551-564.

Wu J, Ai C, Liu Y, Zhang Y, Jiang M, Lv A, Yang L. Interactions between Phytochemicals from Traditional Chinese Medicines and Human Cytochrome P450 Enzymes. Curr Drug Metab. 2012, 13 (5): 599-614.

Mao Y, Li Y, Hao M, Zhang S, Ai C. Docking, molecular dynamics and quantitative structure-activity relationship studies for HEPTs and DABOs as HIV-1 reverse transcriptase inhibitors. J Mol Model. 2012; 18(5):2185-98.

Liu J, Li Y, Zhang S, Ai C, Yan Y. Studies of Phenylethynyl-pyrrolo[1,2-a]pyrazine as mGluR5 Antagonists Using 3D-QSAR Method . Chem Asian J. 2012, 24(1) 238-248.

Yan Y, Li Y, Zhang S, Ai C,Studies of tricyclic piperazine/piperidine furnished molecules as novel integrin αvβ3/αIIbβ3 dual antagonists using 3D-QSAR and molecular docking. J Mol Graph Model, 2011 (29): 747–762.

Liu J, Li Y, Zhang S, Xiao Z and Ai C,Studies of New Fused Benzazepine as Selective Dopamine D3 Receptor Antagonists Using 3D-QSAR, Molecular Docking and Molecular Dynamics. Int J Mol Sci. 2011, 12(2): 1196-1221.

Xu X, Yang W, Wang X, Li Y, Wang Y, Ai C. Dynamic communication between androgen and coactivator: Mutually-induced conformational perturbations in androgen receptor ligand-binding domain. Proteins. 2011; 79(4):1154-71.

Zhang M, Zhang X, Li Y, Fan W, Wang Y, Hao M, Zhang S, Ai C. Investigation on Quantitative Structure Activity Relationships and Pharmacophore Modeling of a Series of mGluR2 Antagonists Int J Mol Sci., 2011; 12 (9 ): 5999-6023.

Zhang B, Li Y, Zhang H, Ai C. 3D-QSAR and Molecular Docking Studies on Derivatives of MK-0457, GSK1070916 and SNS-314 as Inhibitors Against Aurora B Kinase. Int J Mol Sci. 2010, 11(11): 4326-4347.

Ai C, Li Y, Wang Y, Li W, Dong P, Ge G, Yang L. Investigation of binding features: Effects on the interaction between P450 2A6 and inhibitors. J Comput Chem. 2010; 31(9):1822-31.

Wang Y, Li Y, Ma Z, Yang W, Ai C. Mechanism of MicroRNA-Target Interaction: Molecular Dynamics Simulations and Thermodynamics Analysis. PLoS Comput Biol. 2010; 6(7):e1000866.

Wang Z, Li Y, Ai C, Wang Yonghua. In Silico Prediction of Estrogen Receptor Subtype Binding Affinity and Selectivity Using Statistical Methods and Molecular Docking with 2-Arylnaphthalenes and 2-Aryquinolines. Int J Mol Sci. 2010, 11(9): 3434-3458.

Ge G, Zhang R, Ai C, He Y, Zhang Y, Liu X, Yang L, Wang Z, Yang L. Stereochemical differentiation of C-7 hydroxyltaxane isomers by electrospray ionization mass spectrometry. Rapid Commun Mass Sp. 2009, 23(3):425-432.

Dong P, Ge G, Zhang Y, Ai C, Li G, Zhu L, Luan H, Liu X, Yang L. Quantitative Structure-Retention Relationship studies for taxanes including epimers and isomeric metabolites in ultra -fast liquid chromatography. J Chromatogr A. 2009; 1216(42):7055-62.

Ai C, Li Y, Wang Y, Chen Y, Yang L. Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition. Bioorg Med Chem Lett. 2009, 19(3):803-806.

Li W, Liu Y, Zhang J, Ai C, Xiang N, Liu H, Yang L.. Anti-androgen-independent Prostate Cancer Effects of Ginsenoside Metabolites: In Vitro Mechanism and Possible Structure-Activity Relationship Investigation. Arch Pharm Res. 2009; 32(1): 49-57.

Ai C, Li Y, Wang Y, Li Y, Dong P, Ge G, Yang L. A 3-D QSAR Study of Catechol-O-Methyltransferase Inhibitors Using CoMFA and CoMSIA. QSAR Comb Sci. 2008, 27 (10): 1183-1192.

Dong P, Zhang Y, Ge G, Ai C, Liu Y, Yang L, Liu C. Modeling resistance index of taxoids to MCF-7 cell lines using ANN together with electrotopological state descriptors. Acta Pharmacol Sin. 2008, 29(3): 385-396.

李艳红,王永华,杜逊甫,李燕,艾纯芝,杨凌,人类转运蛋白中致病性nsSNPs的预测,辽宁师范大学学报(自然科学版),2008,31(3),317-321.

Ai C, Sun R, Wang C. DFT Studies on Hydrogen Overfall Mechanism for Catalyzed Hydroisomerization of Pentane. Chinese J Struc Chem. 2007, 26(2): 239-247.

艾纯芝,孙仁安,王长生,马琳,正己烷催化异构反应中氢溢流机理的理论研究,高等学校化学学报, 2008,29(1): 182-86。

Sun R, Li N, Ai C, Zhang H. Theoretical Study on the Reaction Mechanism of SiCl4 with H in the Gas Phase. Chinese J. Struct. Chem. 2006, 25(4): 491-496.

Ai C, Sun R, Yan J. Theoretical Study of Decomposition Pathways for Rare-gas-containing Compounds HRgX (Rg = He, Ne, Ar, Kr; X = Cl, Br). Chinese J. Struct. Chem. 2005, 24(12): 1445-1451.

阎 杰, 艾纯芝, 孙仁安,稀有气体化合物HRgX(Rg=He、Ne、Ar、Kr, X=CI、Br) 结构的理论研究,辽宁师范大学学报,2005,28(2),209-212。


 

AUTHORIZED PATENT:

Yang L,Ai C,Ge G,Yu Y,Xia Y,Liu Z, One novel type of targeted anti-cancer agents and its preparation & application. China,2015.6.17, ZL201110386523.0。