Identification of Mammalian Nuclear RNA N6-Adenosine Methylation Complex

Dr. Liu Jianzhao, Ph.D.
The University of Chicago

Introduction

Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs in higher eukaryotes. m6A is widely con¬served among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs. But, the biological functions of m6A modification are largely unknown mostly because the methyltransferase complex itself remains a mystery. In this talk, I will introduce how the human nuclear RNA m6A methyltransferase core complex was for the first time biochemically identified and characterized. The direct RNA binding sites and target genes of the methyltransferase complex were revealed in a transcriptome-wide manner by high-throughput sequencing methods.

About the speaker

Dr. Jianzhao Liu received his BS degree from Zhejiang University in 2006 and PhD degree from The Hong Kong University of Science and Technology in 2011, where he worked with Professor Ben Zhong Tang. He is now doing his postdoc with Professor Chuan He at The University of Chicago.

时间: 2014年6月30日 上午10:30-12:00

地点: 实验楼P203（化学与化工学院学术会议厅）

All are welcome