Calcium Flickers Steer Cell Migration

Dr. Chaoliang Wei

Dept. of Cellular and Molecular Medicine, School of Medicine, Univ. of California

About the Speaker

Sep 1997 - Jul 2001 B.S., Dept. of Life Science, Peking University, Beijing, China.

Major: Physiology and Biophysics

Sep 2001 - Jul 2007 Ph.D., Dept. of Life Science& Institute of Molecular Medicine,

Peking University, Beijing, China.

Major: Biophysics

Mar 2008 - Present Postdoctoral Fellow, Dept. of Cellular and Molecular Medicine,

School of Medicine, Univ. of California, San Diego.

Project: Splicing factors regulate cardiac function.

Talk Introduction

I caught a “hidden” calcium signal activity called “calcium flicker” which was most active at the leading lamella of migrating cells. When exposed to a PDGF gradient, asymmetric calcium flicker activity develops across the lamella and promotes the turning of migrating fibroblasts. The study not only resolved a long-standing paradox about calcium signaling in migrating cells, but also unmasked the underlying molecular basis, which might provide clues for developing new therapies for human diseases.

时间：2015年10月29日上午9:30-10:30

地点：办公楼620-12会议室

All are welcome！