ResearchGate: https://www.researchgate.net/profile/Xinxu-Zhang/research

Google Scholar: https://scholar.google.com/citations?user=Uw2W7LUAAAAJ&hl=en

Research group website: https://www.x-mol.com/groups/mi

Educational background:

2010.09-2016.03，Shanghai Jiao Tong University，Ph.D, Microbiology

2014.03-2014.09，University of Southern California，Visiting scholar, Microbiology

2006.09-2010.06，Nanjing Agricultural University，B.S., Biotechnology

Working experience:

2023.03-Present，Assistant Professor，Institute for Advanced Study, Shenzhen University

2018.03-2023.02，Associate Researcher，Institute for Advanced Study, Shenzhen University

2016.04-2018.02，Postdoctoral Researcher，Marine Biology Institute, Shantou University

Research interests:

1. Marine deep biosphere

2. Aquatic invertebrate immunology

Research Grants:

1. Microbial regulatory mechanism of the methane flux in marine sediments: A case study of the Baltic Sea. 2025.01-2028.12. National Natural Science Foundation of China. PI. 480K RMB.

2. Distribution and metabolism of carbon and nitrogen for archaea in hadal trench sediments: A case study of the Yap Trench. 2020.01-2022.12. National Natural Science Foundation of China. PI. 790K RMB.

3. Metabolic functional diversity of symbiotic microorganisms in the hemolymph of mud crab Scylla paramamosain. 2018.01-2020.12. National Natural Science Foundation of China. PI. 250K RMB.

4. Mechanism of innate immune response mediated by hemolymph microbiota in mud crab Scylla paramamosain. 2025.01-2027.12. Guangdong Province Basic and Applied Basic Research Fund. PI. 100K RMB.

5. Microbiome and metabolic potentials of the hemolymph microorganisms in Scylla paramamosain. 2017.01-2018.02. China Postdoctoral Science Foundation. PI. 50K RMB.

6. The interaction between antimicrobial peptides and symbiotic microorganisms in the hemolymph of shrimp and crab. 2020.05-2023.05. Science and Technology Innovation Committee of Shenzhen. PI. 300K RMB.

7. Mechanism of the host microbiome participating in the accumulation of carotenoids in the noble scallop Chlamys nobilis. 2019.03-2021.03. Science and Technology Innovation Committee of Shenzhen. PI. 300K RMB.

Publications (^#First Author. ^*Corresponding Author):

2022-2025：

1. Rathour R., Ma Y., Xiong J., Wang X., Petersen Jillian^*, Zhang Xinxu^*. Hemolymph microbiota and host immunity of crustaceans and mollusks. ISME J., 2025, wraf133.

2. Yan J.^#, Zhang Xinxu^#, Shi X., Wu J., Zhou Z., Tang Y., Bao Z., Luo N., Zhang Demin^*, Chen J., Zhang Huajun^*. Metagenomic insights into the rapid recovery mechanisms of prokaryotic community and spread of antibiotic resistance genes after seawater disinfection. Water Res., 2025, 271:122887.

3. Sha H., Zhang Xinxu, Chen J., Qiu Q., Xiong Jinbo^*. Prophylactic sarafloxacin hydrochloride increases shrimp susceptibility to AHPND via transferring antibiotic resistance genes and virulence factors. Aquaculture, 2025, 603:742379.

4. Huang Y.^#, Zhang Xinxu^#, Xin Y., Tian J., Li Meng^*. Distinct microbial nitrogen cycling processes in the deepest part of the ocean. mSystems, 2024, 9:e00243-24.

5. Sha H., Song T., Zhan P., Zhang Xinxu, Chen, J., Xiong Jinbo^*. Sarafloxacin hydrochloride exposure disrupts gut microbiota and increases shrimp susceptibility to Vibrio anguillarum infection. Aquaculture, 2024, 586:740810.

6. Zhang Xinxu, Zhang C., Liu Y., Zhang R., Li Meng^*. Non-negligible roles of archaea in coastal carbon biogeochemical cycling. Trends Microbiol., 2023, 31:586-600.

7. Pan J., Zhang Xinxu, Xu W., Liu Y., Liu L., Luo Z., Li Meng^*. Wood-Ljungdahl pathway found in novel marine Korarchaeota groups illuminates their evolutionary history. mSystems, 2023, 8: e00305-23.

8. Zhang Xinxu, Huang Y., Liu Y., Xu W., Pan J., Zheng X., Du H., Zhang C., Lu Z., Zou D., Liu Z., Cai M., Xiong J., Zhu Y., Dong Z., Jiang H., Dong H., Jiang J., Luo Z., Huang L., Li Meng^*. An ancient respiratory system in the widespread sedimentary archaea Thermoprofundales. Mol. Biol. Evol., 2022, 39:msac213.

9. Zhang Xinxu^#, Liu Z.^#, Xu W., Pan J., Huang Y., Cai M., Luo Z., Li Meng^*. Genomic insights into versatile lifestyle of three new bacterial candidate phyla. Sci. China Life Sci., 2022, 65: 1547-1562.

10. Cai M.^#, Duan C.^#, Zhang Xinxu, Pan J., Liu Y., Zhang C., Li Meng^*. Genomic and transcriptomic dissection of Theionarchaea in marine ecosystem. Sci. China Life Sci., 2022, 65:1222-34.

2018-2021：

11. Zhang M.^#, Zhang Xinxu^#, Tran N., Sun Z., Zhang X., Ye H., Zhang Y., Ma H., Aweya J., Li Shengkang^*. Molting alters the microbiome, immune response, and digestive enzyme activity in mud crab (Scylla paramamosain). mSystems, 2021, 6:e00917-21.

12. Lu J.^#, Zhang Xinxu^#, Wang C., Li M., Chen J., Xiong Jinbo^*. Responses of sediment resistome, virulence factors and potential pathogens to decades of antibiotics pollution in a shrimp aquafarm. Sci. Total Environ., 2021, 794:148760.

13. Liu Y.^#, Makarova K.^#, Huang W.^#, Wolf Y., Nikolskaya A., Zhang Xinxu, Cai M., Zhang C., Xu W., Luo Z., Cheng Lei^*, Koonin Eugene^*, Li Meng^*. Expanded diversity of Asgard archaea and their relationships with eukaryotes. Nature, 2021, 593:553-57.

14. Huang W.^#, Liu Y.^#, Zhang Xinxu, Zhang C., Zou D., Zheng S., Xu W., Luo Z., Liu F., Li Meng^*. Comparative genomic analysis reveals metabolic flexibility of Woesearchaeota. Nat. Commun., 2021, 12:5281.

15. Zhang Xinxu^#, Zhang M.^#, Zheng H., Ye H., Zhang X., Li Shengkang^*. Source of hemolymph microbiota and their roles in the immune system of mud crab. Dev. Comp. Immunol., 2020, 102:103470.

16. Zhang Xinxu, Li Meng^*. Distribution and metabolic characteristics of several common archaeal taxa in marine sediments. Acta microbiologica Sinica, 2020, 60:1907-21.

17. Qin Wei^#,*, Zheng Y.^#, Zhao Feng^*, Wang Y., Urakawa, H., Martens-Habbena, W., Liu H., Huang X., Zhang Xinxu, Nakagawa T., Mende D., Bollmann A., Wang B., Zhang Y., Amin S., Nielsen J., Mori K., Takahashi R., Virginia Armbrust E.W., Winkler Mari-K.H., DeLong E., Li M., Lee P., Zhou J., Zhang C., Zhang T., Stahl, D., Ingalls Anitra^*. Alternative strategies of nutrient acquisition and energy conservation map to the biogeography of marine ammonia-oxidizing archaea. ISME J., 2020, 14:2595-2609.

18. Liu H., Zhang C., Zhang Xinxu, Tan K., Zhang H., Cheng D.,Ye T., Li S., Ma H., Zheng Huaiping^*. A novel carotenoids-producing marine bacterium from noble scallop Chlamys nobilis and antioxidant activities of its carotenoid compositions. Food Chem., 2020, 320:126629.

19. Cheng D., Zhang H., Liu H., Zhang Xinxu, Tan K., Li S., Ma H., Zheng Huaiping^*. Identification and molecular characterization of peroxiredoxin 6 from noble scallop Chlamys nobilis revealing its potent immune response and antioxidant property. Fish Shellfish Immunol., 2020, 100:368-377.

20. Liu H., Tan K., Zhang Xinxu, Zhang H., Cheng D., Ye T., Li S., Ma H., Zheng Huaiping^*. Comparison of gut microbiota between golden and brown noble scallop Chlamys nobilis and its association with carotenoids. Front. Microbiol., 2020, 11:36.

21. Gao Y., Du X., Xu W., Fan R., Zhang Xinxu, Yang S., Chen X., Lv J., Luo Zhuhua^*. Fungal diversity in deep sea sediments from east Yap Trench and their denitrification potential. Geomicrobiol. J., 2020, 37:848-58.

22. Wang Y., Zhang Xinxu, Wang J., Xiao X., Wang Fengping^*. Genomic analysis of Marinobacter sp. NP-4 and NP-6 isolated from the deep-sea oceanic crust on the western flank of the Mid-Atlantic Ridge. Mar. Genom., 2020, 50:100693.

23. Li Z., Zhang Xinxu, Aweya J., Wang S., Hu Z., Li Shengkang^*, Wen X. Formulated diet alters gut microbiota compositions in marine fish Nibea coibor and Nibea diacanthus. Aquac. Res., 2019, 50:126-138.

24. Zhang Xinxu, Sun Z., Zhang X., Zhang M., Li Shengkang^*. Hemolymph microbiomes of three aquatic invertebrates as revealed by a new cell extraction method. Appl. Environ. Microbiol., 2018, 84:e02824-17.

25. Wei X.^#, Wang L.^#, Sun W., Zhang M., Ma H., Zhang Y., Zhang Xinxu^*, Li Shengkang^*. C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain. Dev. Comp. Immunol., 2018, 84:213-229.

26. Zhang Xinxu^#, Xu W.^#, Liu Y., Cai M., Luo Zhuhua^*, Li Meng^*. Metagenomics reveals microbial diversity and metabolic potentials of seawater and surface sediment from a hadal biosphere at the Yap Trench. Front. Microbiol., 2018, 9:2402.

27. Reese Brandi^*, Zinke L., Sobol M., LaRowe D., Orcutt B., Zhang Xinxu, Jaekel U., Wang F., Dittmar T., Defforey D., Tully B., Paytan A., Sylvan J., Amend J., Edwards K., Girguis P. Nitrogen cycling of active bacteria within oligotrophic sediment of the Mid-Atlantic Ridge flank. Geomicrobiol. J., 2018, 35:468-83.

2013-2017：

28. Zhang Xinxu, Wu H., Li Z., Li Y., Wang S., Zhu D., Wen X., Li Shengkang^*. Effects of dietary supplementation of Ulva pertusa and non-starch polysaccharide enzymes on gut microbiota of Siganus canaliculatus. J. Oceanol. Limnol., 2017, 36:438-49.

29. Sun W., Zhang Xinxu, Wan W., Wang S., Wen X., Zheng H., Zhang Y., Li Shengkang^*. Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in anti-lipopolysaccharide factors (ALFs) gene expression in mud crab. Dev. Comp. Immunol., 2017, 67:361-376.

30. Zhang Xinxu, Feng X., Wang Fengping^*. Diversity and metabolic potentials of subsurface crustal microorganisms from the western flank of the Mid-Atlantic Ridge. Front. Microbiol., 2016, 7:363.

31. Zhang Xinxu, Fang J., Bach W., Edwards K., Orcutt B., Wang Fengping^*. Nitrogen stimulates the growth of subsurface basalt-associated microorganisms at the western flank of the Mid-Atlantic Ridge. Front. Microbiol., 2016, 7:633.

32. Natarajan V. P.^#, Zhang Xinxu^#, Morono Y., Inagaki F., Wang Fengping^*. A modified SDS-based DNA extraction method for high quality environmental DNA from seafloor environments. Front. Microbiol., 2016, 7:986.

33. Wang Fengping^#,*, Zhang Y.^#, Chen Y., He Y., Qi J., Hinrichs K., Zhang Xinxu, Xiao Xiang^*, Boon N. Methanotrophic archaea possessing diverging methane-oxidizing and electron-transporting pathways. ISME J., 2014, 8:1069-78.

34. Wang F., Zhou Y., Zhang Xinxu, Xiao Xiang^*. Biodiversity of deep-sea microorganisms. Biodiversity Science, 2013, 21:445-455.

Patents:

1. Luo Z., Hu J., Zhang Xinxu, Wang Z., Ling M., Gao Y., Chen X., Xu W. Identification of a polyurethane-degrading yeast and its application. China Invention Patent, ZL202210403010.4.

2. Xu W., Zuo X., Zhang Xinxu, Gao Y., Luo Z. A denitrifying fungus and its application. China Invention Patent, ZL202110374458.3.

3. Xu W., Zuo X., Zhang Xinxu, Gao Y., Luo Z. A highly efficient marine red yeast strain WCBC for removing ammonia and its application. China Invention Patent, ZL202110911129.8.

4. Li S., Zhang Xinxu, Zhang M., Zhang X., Sun Z. A method for accurately counting the abundance of microorganisms in invertebrate hemolymph. China Invention Patent, ZL201711249372.8.

Recruitment:

My research group is recruiting postdoctoral, doctoral, and master's students with a background in microbiology, immunology, bioinformatics, aquaculture, or molecular biology.