Educational background：
2015.09-2018.07 Academy of Military Sciences, Public Health and Preventive Medicine, Ph.D
2012.09-2015.07 Shandong Agriculture University, Food Science and Engineering, Master
2008.09-2012.07 Shandong Agriculture University, Food Science and Engineering, Bachelor
Working experience：
2024.04-present Institute for advanced study, Shenzhen university, PI
2018.07-2024.03, Institute for advanced study, Shenzhen university, Postdoctoral Researcher, Associate Researcher
Research interests：
Archaeal functional evolution and eukaryogenesis, Molecular evolution
Grants：
1. National Natural Science Foundation of China, The role of UEV-Vps23 in ESCRT ubiquitinationUEV-Vps23 in Asgard archaea，2024.01-2027.12，500K RMB，PI.
2. National Natural Science Foundation of China, Membrane scission process of ESCRT in Asgard archaea. 2021.01-2023.12, 240K RMB, PI.
3. National Natural Science Foundation of China, Evolution of endomembrane-like system and associated protein in Archaea, 2024.01-2028.12, 3650K.
4. Basic and Applied Basic Research Foundation of Guangdong Province, Evolution of optimum growth temperature in Asgard archaea based on elongation factor 1A, 2023.01-2025.12, 100 RMB， PI.
5. Basic and Applied Basic Research Foundation of Guangdong Province, Reconstruction of MK-D1 archaeal ESCRT and the evolutionary origin of eukaryotic endomembrane system，2020.01-2022.12, 100K RMB, PI.
6. China Postdoctoral Science Foundation, Exploring ESCRT evolution in Asgard archaea based on evolutionary characteristics of Vps4, 2019.01-2021.03, 50K RMB, PI.
Publications：
1. Zhongyi Lu#; Runyue Xia#; Siyu Zhang; Jie Pan; Yang Liu; Yuri I. Wolf; Eugene V. Koonin; Meng Li*; Evolution of optimal growth temperature in Asgard archaea inferred from the temperature dependence of GDP binding to EF-1A, Nature Communications, 2024, 1(515).
2. Zhongyi Lu#; Siyu Zhang#; Yang Liu#; Runyue Xia; Meng Li*; Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea, Cell Reports, 2024, 43(2).
3. Zhongyi Lu#; Ting Fu#; Tianyi Li; Yang Liu; Siyu Zhang; Jinquan Li; Junbiao Dai; Eugene V. Koonin; Guohui Li; Huiying Chu*; Meng Li*; Coevolution of Eukaryote-like Vps4 and ESCRT-III Subunits in the Asgard Archaea, mBio, 2020, 11(3): e00417-20.
4. Yunchun Yang#; Zhongyi Lu#; Mohammad Azari; Boran Kartal; Huan Du; Mingwei Cai; Graig W. Herbold; Xinghua Ding; Martin Denecke; Xiaoyan Li; Meng Li; Ji-Dong Gu*; Discovery of a new genus of anaerobic ammonium oxidizing bacteria with a mechanism for oxygen tolerance, Water Research, 2022, 226(3).
5. Zhongyi Lu#; Zongbao Liu; Cuijing Zhang; Qiaoyan Wei; Siyu Zhang; Meng Li*; Spatial and seasonal variations of sediment bacterial communities in a river-bay system in South China, Applied Microbiology and Biotechnology, 2021, 105(5): 1979-1989.
6. Zhongyi Lu#; Yong Chen#; Wei Chen#; Hui Liu; Qing Song; Xiaofeng Hu; Ziying Zou; Zhengxiang Liu; Libo Duo; Jiyong Yang; Yanwen Gong; Zhanke Wang; Xuqin Wu; Jingya Zhao; Changjian Zhang; Mengqiang Zhang; Li Han*; Characteristics of qacA/B-positive Staphylococcus aureus isolated from patients and a hospital environment in China, Journal of Antimicrobial Chemotherapy, 2015, 70(3): 653-657.
7. Zhongyi Lu#; Xiaodong Jia; Yong Chen; Xuelin Han; Fangyan Chen; Shuguang Tian; Xueting Su; Zongwei Li; Jingya Zhao; Xi Zhang; Mandong Hu; Liuyu Huang*; Li Han*; Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus, Antimicrobial Agents and Chemotherapy, 2018, 62(5): e01659-17.
8. Yong Chen#; Zhongyi Lu#; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E. Verweij; Liuyu Huang; Li Han*; Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China, Antimicrobial Agents and Chemotherapy, 2016, 60(10): 5878-5884.
