ResearchGate: https://www.researchgate.net/profile/Xinxu-Zhang/research

Google Scholar: https://scholar.google.com/citations?user=Uw2W7LUAAAAJ&hl=en



Educational background:

2010.09-2016.03 Shanghai Jiao Tong University Ph.D, Microbiology

2014.03-2014.09 University of Southern California Visiting scholar, Geomicrobiology

2006.09-2010.06 Nanjing Agricultural University B.S., Biotechnology

Working experience:

2023.03-Present Assistant Professor Institute for Advanced Study, Shenzhen University

2018.03-2023.02 Associate Researcher Institute for Advanced Study, Shenzhen University

2016.04-2018.02 Postdoctoral Researcher Marine Biology Institute, Shantou University

Research interests:

1. Marine microbial ecology

2. Microbial metagenomics

3. Aquaculture microbiology and immunology

Research Grants:

1. Distribution and metabolism of carbon and nitrogen for archaea in hadal trench sediments: A case study of the Yap Trench. 2020.01-2022.12. National Natural Science Foundation of China. PI. 790K RMB.

2. Metabolic functional diversity of symbiotic microorganisms in the hemolymph of mud crab Scylla paramamosain. 2018.01-2020.12. National Natural Science Foundation of China. PI. 250K RMB.

3. Microbiome and metabolic potentials of the hemolymph microorganisms in Scylla paramamosain. 2017.01-2018.02. China Postdoctoral Science Foundation. PI. 50K RMB.

4. The interaction between antimicrobial peptides and symbiotic microorganisms in the hemolymph of shrimp and crab. 2020.05-2023.05. Science and Technology Innovation Committee of Shenzhen. PI. 300K RMB.

5. Mechanism of the host microbiome participating in the accumulation of carotenoids in the noble scallop Chlamys nobilis. 2019.03-2021.03. Science and Technology Innovation Committee of Shenzhen. PI. 300K RMB.

Publications:

1.Zhang Xinxu, Zhang C., Liu Y., Zhang R., Li Meng*. Non-negligible roles of archaea in coastal carbon biogeochemical cycling. Trends Microbiol., 2023. DOI:10.1016/j.tim.2022.11.008.

2.Zhang Xinxu, Huang Y., Liu Y., Xu W., Pan J., Zheng X., Du H., Zhang C., Lu Z., Zou D., Liu Z., Cai M., Xiong J., Zhu Y., Dong Z., Jiang H., Dong H., Jiang J., Luo Z., Huang L., Li Meng*. An ancient respiratory system in the widespread sedimentary archaea Thermoprofundales. Mol. Biol. Evol., 2022, 39:msac213.

3.Zhang Xinxu#, Liu Z.#, Xu W., Pan J., Huang Y., Cai M., Luo Z., Li Meng*. Genomic insights into versatile lifestyle of three new bacterial candidate phyla. Sci. China Life Sci., 2022. (#Co-first author).

4. Zhang M.#,Zhang Xinxu#, Tran N., Sun Z., Zhang X., Ye H., Zhang Y., Ma H., Aweya J., Li Shengkang*. Molting alters the microbiome, immune response, and digestive enzyme activity in mud crab (Scylla paramamosain). mSystems, 2021, 6:e00917-21. (#Co-first author).

5. Lu J.#,Zhang Xinxu#, Wang C., Li M., Chen J., Xiong Jinbo*. Responses of sediment resistome, virulence factors and potential pathogens to decades of antibiotics pollution in a shrimp aquafarm. Sci. Total Environ., 2021, 794:148760. (#Co-first author).

6.Zhang Xinxu, Li Meng*. Distribution and metabolic characteristics of several common archaeal taxa in marine sediments. Acta microbiologica Sinica, 2020, 60:1907-21.

7.Zhang Xinxu#, Zhang M.#, Zheng H., Ye H., Zhang X., Li Shengkang*. Source of hemolymph microbiota and their roles in the immune system of mud crab. Dev. Comp. Immunol., 2019, 102:103470. (#Co-first author).

8.Zhang Xinxu#, Xu W.#, Liu Y., Cai M., Luo Zhuhua*, Li Meng*. Metagenomics reveals microbial diversity and metabolic potentials of seawater and surface sediment from a hadal biosphere at the Yap Trench. Front. Microbiol., 2018, 9:2402. (#Co-first author)

9.Zhang Xinxu, Sun Z., Zhang X., Zhang M., Li Shengkang*. Hemolymph microbiomes of three aquatic invertebrates as revealed by a new cell extraction method. Appl. Environ. Microbiol., 2018, 84:e02824-17.

10. Wei X.#, Wang L.#, Sun W., Zhang M., Ma H., Zhang Y.,Zhang Xinxu*, Li Shengkang*. C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain. Dev. Comp. Immunol., 2018, 84:213-229. (*Co-corresponding author).

11.Zhang Xinxu, Wu H., Li Z., Li Y., Wang S., Zhu D., Wen X., Li Shengkang*. Effects of dietary supplementation of Ulva pertusa and non-starch polysaccharide enzymes on gut microbiota of Siganus canaliculatus. J. Oceanol. Limnol., 2017, 36:438-49.

12.Zhang Xinxu, Feng X., Wang Fengping*. Diversity and metabolic potentials of subsurface crustal microorganisms from the western flank of the Mid-Atlantic Ridge. Front. Microbiol., 2016, 7:363.

13.Zhang Xinxu, Fang J., Bach W., Edwards K., Orcutt B., Wang Fengping*. Nitrogen stimulates the growth of subsurface basalt-associated microorganisms at the western flank of the Mid-Atlantic Ridge. Front. Microbiol., 2016, 7:633.

14. Natarajan V. P.#,Zhang Xinxu#, Morono Y., Inagaki F., Wang Fengping*. A modified SDS-based DNA extraction method for high quality environmental DNA from seafloor environments. Front. Microbiol., 2016, 7:986. (#Co-first author).

15. Cai M.#, Duan C.#,Zhang Xinxu, Pan J., Liu Y., Zhang C., Li Meng*. Genomic and transcriptomic dissection of Theionarchaea in marine ecosystem. Sci. China Life Sci., 2022, 65:1222-34.

16. Liu Y.#, Makarova K.#, Huang W.#, Wolf Y., Nikolskaya A.,Zhang Xinxu, Cai M., Zhang C., Xu W., Luo Z., Cheng Lei*, Koonin Eugene*, Li Meng*. Expanded diversity of Asgard archaea and their relationships with eukaryotes. Nature, 2021, 593:553-57.

17. Huang W.#, Liu Y.#,Zhang Xinxu, Zhang C., Zou D., Zheng S., Xu W., Luo Z., Liu F., Li Meng*. Comparative genomic analysis reveals metabolic flexibility of Woesearchaeota. Nat. Commun., 2021, 12:5281.

18. Qin Wei#,*, Zheng Y.#, Zhao Feng*, Wang Y., Urakawa, H., Martens-Habbena, W., Liu H., Huang X.,Zhang Xinxu, Nakagawa T., Mende D., Bollmann A., Wang B., Zhang Y., Amin S., Nielsen J., Mori K., Takahashi R., Virginia Armbrust E.W., Winkler Mari-K.H., DeLong E., Li M., Lee P., Zhou J., Zhang C., Zhang T., Stahl, D., Ingalls Anitra*. Alternative strategies of nutrient acquisition and energy conservation map to the biogeography of marine ammonia-oxidizing archaea. ISME J., 2020, 14:2595-2609.

19. Liu H., Zhang C.,Zhang Xinxu, Tan K., Zhang H., Cheng D.,Ye T., Li S., Ma H., Zheng Huaiping*. A novel carotenoids-producing marine bacterium from noble scallop Chlamys nobilis and antioxidant activities of its carotenoid compositions. Food Chem., 2020, 320:126629.

20. Cheng D., Zhang H., Liu H.,Zhang Xinxu, Tan K., Li S., Ma H., Zheng Huaiping*. Identification and molecular characterization of peroxiredoxin 6 from noble scallop Chlamys nobilis revealing its potent immune response and antioxidant property. Fish Shellfish Immunol., 2020, 100:368-377.

21. Liu H., Tan K.,Zhang Xinxu, Zhang H., Cheng D., Ye T., Li S., Ma H., Zheng Huaiping*. Comparison of gut microbiota between golden and brown noble scallop Chlamys nobilis and its association with carotenoids. Front. Microbiol., 2020, 11:36.

22. Gao Y., Du X., Xu W., Fan R.,Zhang Xinxu, Yang S., Chen X., Lv J., Luo Zhuhua*. Fungal diversity in deep sea sediments from east Yap Trench and their denitrification potential. Geomicrobiol. J., 2020, 37:848-58.

23. Wang Y.,Zhang Xinxu, Wang J., Xiao X., Wang Fengping*. Genomic analysis of Marinobacter sp. NP-4 and NP-6 isolated from the deep-sea oceanic crust on the western flank of the Mid-Atlantic Ridge. Mar. Genom., 2020, 50:100693.

24. Li Z.,Zhang Xinxu, Aweya J., Wang S., Hu Z., Li Shengkang*, Wen X. Formulated diet alters gut microbiota compositions in marine fish Nibea coibor and Nibea diacanthus. Aquac. Res., 2019, 50:126-138.

25. Reese Brandi*, Zinke L., Sobol M., LaRowe D., Orcutt B.,Zhang Xinxu, Jaekel U., Wang F., Dittmar T., Defforey D., Tully B., Paytan A., Sylvan J., Amend J., Edwards K., Girguis P. Nitrogen cycling of active bacteria within oligotrophic sediment of the Mid-Atlantic Ridge flank. Geomicrobiol. J., 2018, 35:468-83.

26. Sun W.,Zhang Xinxu, Wan W., Wang S., Wen X., Zheng H., Zhang Y., Li Shengkang*. Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in anti-lipopolysaccharide factors (ALFs) gene expression in mud crab. Dev. Comp. Immunol., 2017, 67:361-376.

27. Wang Fengping*,#, Zhang Y.#, Chen Y., He Y., Qi J., Hinrichs K.,Zhang Xinxu, Xiao Xiang*, Boon N. Methanotrophic archaea possessing diverging methane-oxidizing and electron-transporting pathways. ISME J., 2014, 8:1069-78.

28. Wang F., Zhou Y.,Zhang Xinxu, Xiao Xiang*. Biodiversity of deep-sea microorganisms. Biodiversity Science, 2013, 21:445-455.

Patents:

1. Li S.,Zhang Xinxu, Zhang M., Zhang X., Sun Z. A method for accurately counting the abundance of microorganisms in invertebrate hemolymph. China Invention Patent, 2021.