Education

2011, Ph.D. School of Medicine and Public Health, University of Wisconsin-Madison, WI, USA

2004, B.S. School of Life Science, Xiamen Unversity, China

Positions/Employment

2011-2015 Postdoctoral Fellow, Dept Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

2006-2011 Research Assistant, Dept Obstetrics and Gynecology, University of Wisconsin-Madison, WI

Research Interests

DNA/RNA methylation in atherogenesis

Single-cell next generation sequencing in the endothelial heterogeneity

Stream-lined and drug-eluted stent

Fetal origin of cardiovascular disease

Professional Members

2012-present Member, American Heart Association

2012-present Member, Biomechanics in Vascular Biology & Cardiovascular Disease

2009- 2011 Member, Society for the Study of Reproduction

2004-2006 Member, Society for Gynecologic Investigation

Selected Presentations

Arteriosclerosis, Thrombosis, and Vascular Biology, Peripheral Vascular Disease 2015 Scientific Sessions, San Francisco, California. Title: Hypercholesterolemia suppresses carotid artery endothelial NOS3 expression via epigenetic mechanisms. (May 2015)

Systems Biology Approaches to Understanding Atherosclerosis. British Atherosclerosis Society, Cambridge, UK. Title: Differential DNA Methylation Patterns of Athero-Susceptible and Protected Endothelial Phenotypes In Vivo: Epigenomic Code In Arterial Endothelial Methylome (September 2014).

9th International Symposium on Biomechanics, Vascular Biology and Cardiovascular Disease. Montreal, Canada. Title: Differential DNA methylation of endothelial Kruppel-like Factor 4 (KLF4) promoter in response to hemodynamic disturbed flow in vitro and in vivo. (April 2014).

Honors and Awards

2012-2014 AHA Postdoctoral Research Fellowship

2013 Research Excellence: - American Heart Association in Recognition of Outstanding Dedication and Achievement in Heart Disease and Stroke Research

2009 University of Wisconsin-Madison, ERP Director’s Award for Recognition of Merit and Achievement in Thesis Research.

Peer Reviewed Publications

1.Chen D, Dai C,Jiang YZ*. Histone H2A and H2B Deubiquitinase in Developmental Disease and Cancer. Cancer Transl Med 2015;1(5):170-5.*corresponding author

2.Chen DM, Zhong XQ, Wang K,Jiang YZ*. SWI/SNF Chromatin Remodeling Complex in Regulating Mesenchymal Stem Cell Lineage Specification. J Tissue Sci Eng 2015;6: 154. doi:10.4172/2157-7552.1000154.*corresponding author

3.Zhu XX, Ya-Wei Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Dong-Bao Chen DB,Jiang YZ*. Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2016;Aug. Online ISSN: 1949-2553. *corresponding author

4.McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH ,Jiang YZ, Stoeckert CJ , Barker AJ, Markl M, Davies PF. Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome. J Am Heart Assoc. 2016 Apr 18;5(4). pii: e003170. doi: 10.1161/JAHA.115.003170.

5.Jiang YZ, Manduchi E, Jiménez JM, Davies PF. Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arteriosclerosis Thrombosis and Vascular Biology. 2015 Jun;35(6):1317-26. (Editor’s Pick)

6.Jiang YZ*, Manduchi E*, Stoeckert CJ, Davies PF. Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics. 2015, 16:506 doi:10.1186/s12864-015-1656-4 *joint 1st authors.

7.Jiang YZ, Jiménez JM, Ou K, McCormick ME, Davies PF. Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo. Circulation Research. 2014 Jun 20;115(1):32-43.

8.Davies PF.,Jimenez JM, Manduchi E, Stoeckert CJ,Jiang YZ. Emerging topic: flow-related epigenetic regulation of the atherosusceptible endothelial phenotype through DNA methylation.Vascular Pharmacology. 2014 Aug;62(2):88-93.

9.Jiménez JM, Prasad V, Yu M, Kampmeyer C, Kaakour A-H, Wang P, Maloney SF, Wright N, Johnston I,Jiang YZ, Davies PF. Macro- and micro-scale hemodynamics of model coronary stents: Strut geometry, fibrin deposition and thrombomodulin expression. Journal of the Royal Society Interface. 2014. 19:11(94):20131079.

10.Jiang YZ, Li Y, Wang K, Dai CF, Huang SA, Chen DB, Zheng J. Distinct Roles of HIF1A in Endothelial Adaptations to Physiological and Atmospheric Oxygen. Molecular & CellularEndocrinology. 2014. Jun 25;391(1-2):60-67.

11.Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Transcriptionaland Functional Adaptations of Human Endothelial Cells to Physiological Chronic Low Oxygen. Biology of Reproduction. 2013. 88:114.

12.Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Enhanced Cellular Responses and Distinct Gene Profiles in Human Fetoplacental Artery Endothelial Cells under Chronic Low Oxygen. Biology of Reproduction. 2013.89(6):133.

13.Jiang YZ*, Wang K*, Fang R, Zheng J.Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. Journal of Histochemistry & Cytochemistry. 2010. 58:679-685. *joint 1st authors.

14.Dai CF,Jiang YZ, Zheng J. Expression and Roles of Slit-Robo System in Human Ovarian Cancer. Histochemistry and Cell Biology. 2011.135(5):475-485..

15.Wang K,Jiang YZ, Chen DB, Zheng J.Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways.Placenta. 2009.30:1045-1051.

16.Wang K, Li Y,Jiang YZ, Dai CF, Patankar MS, Song JS, Zheng J. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells.Cancer Letter. 2013. Oct 28;340(1):63-71.

17.Li Y,Wang K,Jiang YZ, Dai CF, Zheng J.2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Inhibits Human Ovarian Cancer Cell Proliferation. Cellular Oncology. 2014. Dec;37(6):429-37.

18.Jobe SO, Ramadoss J, Koch JM,Jiang YZ, Zheng J, Magness RR. Estradiol-17β and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta.Hypertension. 2010.55:1005-1011.