Educational background:
2015.09-2018.07 Academy of Military Sciences, Public Health and Preventive Medicine, Ph.D
2012.09-2015.07 Shandong Agriculture University, Food Science and Engineering, Master
2008.09-2012.07 Shandong Agriculture University, Food Science and Engineering, Bachelor
Working experience:
2024.04-present Institute for advanced study, Shenzhen university, PI
2018.07-2024.03, Institute for advanced study, Shenzhen university, Postdoctoral Researcher, Associate Researcher
Research interests:
Archaeal functional evolution and eukaryogenesis, Molecular evolution
Grants:
1. National Natural Science Foundation of China, The role of UEV-Vps23 in ESCRT ubiquitinationUEV-Vps23 in Asgard archaea,2024.01-2027.12,500K RMB,PI.
2. National Natural Science Foundation of China, Membrane scission process of ESCRT in Asgard archaea. 2021.01-2023.12, 240K RMB, PI.
3. National Natural Science Foundation of China, Evolution of endomembrane-like system and associated protein in Archaea, 2024.01-2028.12, 3650K.
4. Basic and Applied Basic Research Foundation of Guangdong Province, Evolution of optimum growth temperature in Asgard archaea based on elongation factor 1A, 2023.01-2025.12, 100 RMB, PI.
5. Basic and Applied Basic Research Foundation of Guangdong Province, Reconstruction of MK-D1 archaeal ESCRT and the evolutionary origin of eukaryotic endomembrane system,2020.01-2022.12, 100K RMB, PI.
6. China Postdoctoral Science Foundation, Exploring ESCRT evolution in Asgard archaea based on evolutionary characteristics of Vps4, 2019.01-2021.03, 50K RMB, PI.
Publications:
1. Zhongyi Lu#; Runyue Xia#; Siyu Zhang; Jie Pan; Yang Liu; Yuri I. Wolf; Eugene V. Koonin; Meng Li*; Evolution of optimal growth temperature in Asgard archaea inferred from the temperature dependence of GDP binding to EF-1A, Nature Communications, 2024, 1(515).
2. Zhongyi Lu#; Siyu Zhang#; Yang Liu#; Runyue Xia; Meng Li*; Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea, Cell Reports, 2024, 43(2).
3. Zhongyi Lu#; Ting Fu#; Tianyi Li; Yang Liu; Siyu Zhang; Jinquan Li; Junbiao Dai; Eugene V. Koonin; Guohui Li; Huiying Chu*; Meng Li*; Coevolution of Eukaryote-like Vps4 and ESCRT-III Subunits in the Asgard Archaea, mBio, 2020, 11(3): e00417-20.
4. Yunchun Yang#; Zhongyi Lu#; Mohammad Azari; Boran Kartal; Huan Du; Mingwei Cai; Graig W. Herbold; Xinghua Ding; Martin Denecke; Xiaoyan Li; Meng Li; Ji-Dong Gu*; Discovery of a new genus of anaerobic ammonium oxidizing bacteria with a mechanism for oxygen tolerance, Water Research, 2022, 226(3).
5. Zhongyi Lu#; Zongbao Liu; Cuijing Zhang; Qiaoyan Wei; Siyu Zhang; Meng Li*; Spatial and seasonal variations of sediment bacterial communities in a river-bay system in South China, Applied Microbiology and Biotechnology, 2021, 105(5): 1979-1989.
6. Zhongyi Lu#; Yong Chen#; Wei Chen#; Hui Liu; Qing Song; Xiaofeng Hu; Ziying Zou; Zhengxiang Liu; Libo Duo; Jiyong Yang; Yanwen Gong; Zhanke Wang; Xuqin Wu; Jingya Zhao; Changjian Zhang; Mengqiang Zhang; Li Han*; Characteristics of qacA/B-positive Staphylococcus aureus isolated from patients and a hospital environment in China, Journal of Antimicrobial Chemotherapy, 2015, 70(3): 653-657.
7. Zhongyi Lu#; Xiaodong Jia; Yong Chen; Xuelin Han; Fangyan Chen; Shuguang Tian; Xueting Su; Zongwei Li; Jingya Zhao; Xi Zhang; Mandong Hu; Liuyu Huang*; Li Han*; Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus, Antimicrobial Agents and Chemotherapy, 2018, 62(5): e01659-17.
8. Yong Chen#; Zhongyi Lu#; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E. Verweij; Liuyu Huang; Li Han*; Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China, Antimicrobial Agents and Chemotherapy, 2016, 60(10): 5878-5884.