报告题目: The magic of chemistry…When interfacing with biology: Development and applications of PET radiopharmaceuticals for imaging and diagnosis of diseases
主讲嘉宾:黄艺耘 教授
主持人: 熊海 研究员
地点:理工楼L1-707
时间:2018年10月18日 14:30
嘉宾简介:
黄艺耘(1961.12-),男,1982年获天津大学化学工程学士,1985年获上海医药工业研究院药物化学硕士,1993年获美国阿克伦(University of Akron)大学有机化学博士学位,1993年在匹兹堡大学医学院PET中心进行博士后研究,1997年升任助理教授,后在哥伦比亚大学医学院和耶鲁大学医学院分别担任助理教授,副教授。现为耶鲁大学医学院放射和医学影像学教授,并任耶鲁大学医学院PET中心联合主任,兼化学部主任。2017年获得美国放射学及生物医学影像研究院(Academy for Radiology and Biomedical Imaging Research)授予的杰出研究者奖(Distinguished Investigator Award)。
黄教授主要致力于新型正电子放射性药物的研发和改进,重点研究用于神经、精神疾病,药物滥用, 代谢系统疾病, 肿瘤等疾病PET显像的正电子放射性药物的开发及临床转化。黄教授先后获得美国国立卫生研究所(NIH)多项国家级基金及私立研究机构的基金资助,在知名期刊上发表相关的SCI论文共200余篇,专利4项。黄教授曾任多个国家的科学基金评委,多家科学期刊的编委和审稿人,和大型国际学术会议的组织委员和论文评委。同时黄教授还与许多大型的制药公司如辉瑞、雅培,礼来等进行合作研发新型的正电子放射药物并用于临床药物研发。
报告摘要:
Positron Emission Tomography (PET) is a powerful molecular imaging technique with unparalleled specificity. The specificity of PET imaging derives from PET radiochemistry. The availability of specific PET radiotracers is essential to the realization of the full power of PET imaging. PET radiotracers are biologically active molecules labeled with positron-emitting radionuclide. They interact with specific proteins, enzymes and biochemical processes in vivo. Information gleaned from these interactions through PET imaging makes it possible to probe the physiology, pharmacology, and the state of biochemical processes in the living system. This presentation will seek to illustrate the applications of PET imaging to probe the molecular basis of disease pathophysiology, which in turn can be used to inform drug development, to optimize treatment strategies, and to monitor the efficacy of existing and emerging therapies. As a highly sensitive and specific molecular imaging tool PET imaging will play an important role in precision medicine and personalized care.