报告主题：From Viral Receptor Discovery to Engineered Antiviral Decoys: Combating EV-D68 Infection

主讲人：魏伟教授（吉林大学第一医院）

主持人：李猛教授

时间：2025年6月17日周二10：00

地点：深圳大学致知楼706

嘉宾简介：

魏伟，教授、博士生导师、国家优青、吉林大学唐敖庆领军教授、艾滋病与病毒研究所副所长。长期从事病毒元件与宿主互作研究，以通讯作者身份在Cell Host & Microbe（x3）、Nature Communications（x2）、Cell Reports、EMBO Reports、Science Signaling、STTT、mBio、Journal of Virology等期刊已发表学术论文40余篇。承担国家自然科学基金委优秀青年科学基金等国家省部级科研任务十余项，获教育部自然科学奖一等奖等荣誉，担任国家自然科学基金通讯评审和会议评审专家，Cell Host & Microbe、Nature Communications、Cell Reports等学术期刊审稿专家。

报告摘要：

Enterovirus D68 (EV-D68) is a leading non-polio enterovirus that causes severe respiratory diseases and poliomyelitis-like illness in children. Viral entry represents a potential multifaceted target for antiviral intervention; however, there are no approved inhibitors to block EV-D68. Here, we identify the functionally undescribed membrane protein major facilitator superfamily-domain-containing protein 6 (MFSD6) as an EV-D68 entry factor amenable to therapeutic intervention. Specifically, MFSD6 expression is crucial for EV-D68 replication. MFSD6 binds to EV-D68 particles and is necessary for virus attachment to cells. The second extracellular domain of the MFSD6 molecule is involved in the recognition of EV-D68. On the basis of these findings, we engineered a recombinant protein complex comprising the MFSD6 ectodomain fused to Fc (MFSD6-Fc(CH3)), which potently inhibited EV-D68 uptake. MFSD6-Fc(CH3) effectively blocked EV-D68 infection in vitro and prevented lethality in newborn mice. In conclusion, our study not only identifies MFSD6 as an EV-D68 entry factor but also reveals a potential antiviral target and therapeutic agent.