教育背景：

2006-2012年　  德国奥斯纳布吕克大学(Osnabrück)和明斯特大学(Münster)纳米技术中心　   理学博士

2001-2004年　  中科院兰州化学物理研究所　　   理学硕士

1997-2001年　  南昌大学　   理学学士

工作经历：

2016-至今　  深圳大学　  研究员

2012-2016年　  耶鲁大学　  博士后

2004-2006年　  中科院上海有机化学研究所　  研究助理

研究方向：

响应与分析：荧光分子探针在生物分析物与金属离子等方面的识别检测与应用

化学合成：非天然核酸的化学修饰和功能团化

    DNA生物传感 / 细胞影像

    DNA纳米自组装及其药物控释

    DNA/polymer荧光水凝胶的制备及应用

生物合成：定位装载非天然氨基酸和修饰蛋白的功能团化

材料性能：DNA与微孔材料或金属纳米框架材料之间的界面性能研究

    超分子发光材料（COF和MOF）

    二维-氧化石墨烯

    一维-碳量子点

所获奖励：

2018年　广东省珠江人才计划－青年拔尖人才

2017年  深圳市南山区领航人才

2016年  深圳市海外高层次人才(孔雀计划)

学术兼职：

Chinese Chemical Letters: 青年编委

Frontiers in Bioengineering and Biotechnology: 专刊客座编辑-Lead Guest Editor

科研项目：

1). 深圳市海外高层次人才- “孔雀计划” 项目，2017/11-2020/12，结题，主持；

2). 深圳市科创委基础研究-自由探索项目，2018/04-2020/03，结题，主持；

3). 深圳市海外高层次人才创新创业计划-孔雀技术创新项目，2019/03-2021/03，结题，主持;

4). 深圳大学青年教师-科研启动项目，2020/01-2022/12，结题，主持;

5). 深圳大学与台北科技大学学术合作-专题研究项目，2021/01-2021/12，结题，主持；

6). 深圳市科创委基础研究-面上项目，2021/10-2024/10，在研，主持；

7). 广东省教育厅广东高校-重点领域专项，2022.01-2024.12，在研，主持；

发表论文（2016年-至今）

27. Jingduo Gao#, Haixiang Pei#, Fang Lv#, Xin Niu, Yu You, Liang He, Shijia Hu, Karan M Shah, Mingyao Liu, Yihua Chen, Bing Du*, Hai Xiong*, Jian Luo*, Small molecule JD-312 programs stem cell fate for osteoarthritis treatment. 2023, submitted.

26. Farid Ahmed, Muhammad Muzammal Hussain, Waheed Ullah Khan, and Hai Xiong*, Exploring Recent Advancements and Future Prospects on Coordination Self-Assembly of the Regulated Lanthanide-Doped Luminescent Supramolecular Hydrogels. Coordination Chemistry Reviews, 2023, under review.

25. Yating Zeng, Ziyan Wang, Linyu Zeng, and Hai Xiong*, Enhancing or Quenching of Mitochondria Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+ and Stimulated Response of GSH. Analytic Chemistry, 2023, under review.

24. Muhammad Muzammal Hussain, Fengli Li, Farid Ahmed, Waheed Ullah Khan, Hai Xiong*, Fluorescence Switch Based on NIR-emitting Carbon Dots Revealing Multi-resistance in the Rapid Response and Cell Bioimaging of Oxytetracycline. Talanta, 2023, under review.

23. Hai Xiong* and Fengli Li, Recent and Emerging Trends of Hybridized COFs Nanoprobes Based on DNA/RNA Biosensors for Analytes Detection and Biomarkers Imaging in Clinical Biomedicines. Trends in Analytical Chemistry, 2023, under review.

22. Waheed Ullah Khan, Weiqing Xu, Yating Zeng, Muhammad Muzammal Hussain, Farid Ahmed and Hai Xiong*, Effective Fluorescent ON-OFF-ON Sensors Based on Nitrogen-doped Carbon Dots for the Recognition of Fe3+ and Lysine. Talanta,2023, under review.

21. Farid Ahmed, Weiqing Xu, Muhammad Muzammal Hussain, Waheed Ullah Khan and Hai Xiong*, Bioimaging-guided Discrimination of Normal/Cancer Cells and Bacteria using Ag+-Mediated Red Fluorescent Carbon Dots. Chemical Engineering Journal, 2023, revision.

20. Waheed Ullah Khan, Muhammad Muzammal Hussain, Farid Ahamd and Hai Xiong*, A review of the growing trend towards heteroatoms-doped carbon dots based on dopamine acting as a hybrid agent and detected analyte. Talanta, 2023, 265, 124781.

19. Muhammad Muzammal Hussain, Waheed Ullah Khan, Farid Ahmed, and Hai Xiong*, Recent developments of Red/NIR-CDs in biosensing, bioimaging, and tumor theranostics. Chemical Engineering Journal, 2023, 465, 143010.

18. Jabrane Jouha, Fengli Li, and Hai Xiong*, A Fluorescence Biosensor Based on DNA Aptamers-COF for Highly Selective Detection of ATP and Thrombin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 295, 122615.

17. Weiqing Xu, Farid Ahmed, and Hai Xiong*, A mitochondria-targeted fluorescent probe based on biocompatible RBH-U for the enhanced response of Fe3+ in living cells and quenching of Cu2+ in vitro. Analytica Chimica Acta, 2023, 1249, 340925.

16. Xue-Yan Yang, Bo Yuan, Hai Xiong*, Yahao Zhao, Lu Wang, San-Qi Zhang,* and Shuai Mao*, Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs. Bioorganic Chemistry, 2022, 129, 106154.

15. Long Zhao, Farid Ahmed, Yating Zeng, Weiqing Xu, and Hai Xiong*. Recent Developments in G‑Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes. ACS Sensors, 2022, 7, 2833−2856.

14. Farid Ahmed, Shahzad Iqbal, and Hai Xiong*, Multifunctional Dual Emissive Fluorescent Probe Based on Europium-doped Carbon Dots (Eu-TCA/NCDs) for Highly Selective Detection of Chloramphenicol, Hg2+ and Fe3+. Environmental Science-Nano, 2022, 9, 2624-2637. (正封面文章)

13. Jabrane Jouha, Fengli Li, Wen-Ta Su*, Chenguang Fan*, Dayong Yang*, and Hai Xiong*, Editoral: Engineering Nucleic Acids-based Functional Nanomaterials, Nanodrugs, and Biosensors. Frontiers in Bioengineering and Biotechnology, 2022, 10, 915229.

12. Shahzad Iqbal, Farid Ahmed, Ziyan Wang, Weiqing Xu, Yating Zeng, and Hai Xiong*. Multi-stimuli Responsive Poly(N-isopropyl-co-tetraphenylethene) acrylamide Copolymer Mediating AIEgens by Controllable Tannic Acid. Polymer, 2022, 249, 124824.

11. Haixiang Pei, Weikai Guo, Yangrui Peng, Hai Xiong, and Yihua Chen*. Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective. Medicinal Research Reviews, 2022, 42, 1607–1660.

10. Long Zhao, Farid Ahmed, and Hai Xiong*, An excimer ‘ON –OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection. Chinese Chemical Letters, 2022, 33, 4243–4247.

9. Jabrane Jouha, and Hai Xiong*, DNAzyme-Functionalized nanomaterials: Recent Preparation, Current Applications, and Future Challenges. Small, 2021, 17, 2105439. (封面文章)

8. Farid Ahmed, Shahzad Iqbal, Long Zhao, and Hai Xiong*, “ON-OFF-ON” fluorescence switches based on N,S-doped carbon dots: Facile hydrothermal growth, selective detection of Hg2+, and as a reversive probe for guanine. Analytica Chimica Acta, 2021, 1183, 338977.

7. Shahzad Iqbal, Farid Ahmed, and Hai Xiong*, Responsive-DNA hydrogel based intelligent materials:  Preparation and applications. Chemical Engineering Journal, 2021, 420, 130384.

6. Qiuyun Xiao, Xuan Zhao, and Hai Xiong*, Biocompatible and noncytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids. Chinese Chemical Letters, 2021, 32, 1687–1690. (正封面文章)

5. Ming-Liang Han, Wei Huang, Yu-Wen Liu, Min Liu, Hui Xu*, Hai Xiong*, and Hui-Xiong Dai*, Pd-Catalyzed Asymmetric Dearomatization of Indoles via Decarbonylative Heck-Type Reaction of Thioesters. Organic Letters, 2021, 23, 172−177.

4. Xuan Zhao, Long Zhao, Qiuyun Xiao, and Hai Xiong*, Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels. Chinese Chemical Letters, 2021, 32, 1363–1366.

3. Farid Ahmed, and Hai Xiong*, Recent developments in 1,2,3-triazole-based chemosensors. Dyes and Pigments, 2021, 185, 108905.

2. Farid Ahmed, Humaira Kabir, and Hai Xiong*, Dual Colorimetric Sensor for Hg2+/Pb2+ and an Efficient Catalyst Based on Silver Nanoparticles Mediating by the Root Extract of Bistorta Amplexicaulis. Frontiers in Chemistry, 2020, 8, 591958.

1. Qiuyun Xiao, Zihan Liu, Xuan Zhao, and Hai Xiong*, Multiple Site-specific One-Pot Synthesis of Two Proteins by the Bio-orthogonal Flexizyme System. Frontiers in Bioengineering and Biotechnology, 2020, 8, 37.

中国专利（2016年-至今）

1.熊海*，肖秋芸，赵烜，中国专利号：2019106243635；申请日：2019.07.11

2.熊海*，赵烜，肖秋芸，中国专利号：201911244688.7；申请日：2019.12.07

3.熊海*，肖秋芸，赵烜，中国专利号：ZL202010830904.2；申请日：2020.08.18. 授权公告号：CN112111267B 授权日：2022.09.30.

4.熊海*，赵龙，中国专利号：ZL202110295806.8；申请日：2021.03.19. 授权公告号：CN113087753B 授权日：2022.10.18.

5.熊海*, 李凤丽, Farid Ahmed, 中国专利号: 202210284234.8；申请日：2022.03.23. 授权公告号：CN 114736671B 授权日：2023.07.04.

6.熊海*, 徐伟清, 中国专利号: 202210932834.0；申请日：2022.08.04

7.熊海*, 李凤丽, Jabrane Jouha, 中国专利号: 202211683805.1；申请日：2022.12.27

8.熊海*, 曾雅婷, 王子琰, 中国专利号: 202310465481.2；申请日：2023.04.21

9.熊海*, 徐伟清, Waheed Ullah Khan, 中国专利号: 202310870589.X；申请日：2023.07.17

10.熊海*, 曾雅婷, 中国专利号: 202310892583.2；申请日：2023.07.24

Book-Chapter

SPRINGER NATURE:  Book entitled “Metal, Metal-Oxides and Metal Sulfides for Batteries, Fuel Cells, Solar Cells, Photocatalysis and Health Sensors” 2021, ISBN 978-3-030-63791-0 (eBook)

Chapter 8: Developing Trends in DNA Biosensor and Their Applications ---Chandrasekar Selvaraj, Srinivas Bitta Thirumalavenkata and Hai Xiong*---

部分发表论文（2004-2016年）

H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme. Angew. Chem. Int. Ed. 2016, 55, 4083-4086.

C. Fan*, H. Xiong, N. Reynolds and D. Söll*, Rationally evolving tRNAPyl for efficient incorporation of noncanonical amino acids. Nucleic Acid Research. 2015, 43(22): e156

H. Xiong and F. Seela*, Cross-Linked DNA: Site Selective “Click” Ligation in Duplexes with Bis-Azides and Stability Changes Caused by Internal Cross-Links. Bioconjugate Chem., 2012, 23, 1230-1243.

H. Xiong, P. Leonard and F. Seela*, Construction and Assembly of Branched Y-shaped DNA: “Click” Chemistry Performed on Dendronized 8-Aza-7-deazaguanine. Oligonucleotides. Bioconjugate Chem., 2012, 23, 856-870.

H. Xiong and F. Seela*, Stepwise “Click” Chemistry for the Template Independent Construction of a Broad Variety of Cross-linked Oligonucleotides: Influence of Linker Length, Position and Linking Number on DNA Duplex Stability. J. Org. Chem., 2011, 76, 5584-5597.

G. Qing, H. Xiong (Co-first authors), F. Seela* and T. Sun*, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites. J. Am. Chem. Soc., 2010, 132, 15228-15232.

H. Xiong, F. Shi, J. Peng and Y. Deng*, Synthesis of supported gold catalysts for selective oxidation of cyclohexane with air. Chin. J. Mol. Catal., 2005, 19(3), 204-207.

H. Xiong, F. Shi and Y. Deng*, Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene. Chin. J. Catal., 2004, 25(11), 887-891.