教育背景：
2006-2012年 德国奥斯纳布吕克大学(Osnabrück)和明斯特大学(Münster)纳米技术中心 理学博士
2001-2004年 中科院兰州化学物理研究所 理学硕士
1997-2001年 南昌大学 理学学士
工作经历：
2016-至今 深圳大学 研究员
2012-2016年 耶鲁大学 博士后
2004-2006年 中科院上海有机化学研究所 研究助理
研究方向：
响应与分析：荧光分子探针在生物分析物与金属离子等方面的识别检测与应用
化学合成：非天然核酸的化学修饰和功能团化
DNA生物传感 / 细胞影像
DNA纳米自组装及其药物控释
DNA/polymer荧光水凝胶的制备及应用
生物合成：定位装载非天然氨基酸和修饰蛋白的功能团化
材料性能：DNA与微孔材料或金属纳米框架材料之间的界面性能研究
超分子发光材料（COF和MOF）
二维-氧化石墨烯
一维-碳量子点
所获奖励：
2018年 广东省珠江人才计划－青年拔尖人才
2017年 深圳市南山区领航人才
2016年 深圳市海外高层次人才(孔雀计划)
学术兼职：
Chinese Chemical Letters: 青年编委
Frontiers in Bioengineering and Biotechnology: 专刊客座编辑-Lead Guest Editor
科研项目：
1). 深圳市海外高层次人才- “孔雀计划” 项目，2017/11-2020/12，结题，主持；
2). 深圳市科创委基础研究-自由探索项目，2018/04-2020/03，结题，主持；
3). 深圳市海外高层次人才创新创业计划-孔雀技术创新项目，2019/03-2021/03，结题，主持;
4). 深圳大学青年教师-科研启动项目，2020/01-2022/12，结题，主持;
5). 深圳大学与台北科技大学学术合作-专题研究项目，2021/01-2021/12，结题，主持；
6). 深圳市科创委基础研究-面上项目，2021/10-2024/10，在研，主持；
7). 广东省教育厅广东高校-重点领域专项，2022.01-2024.12，在研，主持；
组内成员：
副研究员
2023-2026 Farid Ahmed, 超分子化学，巴基斯坦卡拉奇大学（Karachi University）
博士后
2021-2023 Waheed Ullah Khan, 材料物理与化学, 兰州大学
2022-2024 Muhammad Muzammal Hussain, 大连理工大学
2022-2024 金旺锐，生物化学与分子生物学，华东师范大学
2023-2025 Saima Hameed，材料物理与化学, 浙江大学
Alumni 博士后
2018-2020 Chandrasekar Selvaraj，有机化学，印度理工学院Madras分校（Indian Institute of Technology, Madras）
2018-2021 Srinivas Bitta Thirumalavenkata，有机化学，印度化学技术研究所（Indian Institute of Chemical Technology, Hyderabad）
2018-2020 肖秋芸，微生物，华中科技大学
2019-2021 韩明亮，有机化学，南开大学
2019-2021 赵龙，有机化学，德国亚琛工业大学（RWTH Aachen University）
2020-2022 Shahzad Iqbal，核酸化学，四川大学
2019-2022 Farid Ahmed, 超分子化学，巴基斯坦卡拉奇大学（Karachi University）
2021-2023 Jabrane Jouha，有机化学，法国奥尔良大学（University of Orléans）
2021-2023 裴海翔，生物化学与分子生物学，华东师范大学
研究生
赵烜，化学，2018-2021
曾雅婷，生命健康与环境，2021-2024
徐伟清，生命健康与环境，2021-2024
李凤丽，生命健康与环境，2022-2025
曾琳钰，生命健康与环境，2022-2025
雷祺钰，生命健康与环境，2022-2025
本科生
赵烜，2014-2018 读研（本组）
徐浩然，2015-2019 澳大利亚留学
刘姿含，2016-2020 瑞典留学
杨鑫晨，2016-2020
陈瀚，2016-2020
徐悦芃，2020-2024
刘政，2021-2025
发表论文（2016年-至今）
23.Hai Xiong†, Te-Yang Huang†, Yu-Lo Chang, Wen-Ta Su*, Optimization extracts of Achyranthes bidentate and prevents inflammatory responses in IL-1β-induced chondrocytes, 2023, under review.
22. Jingduo Gao#, Haixiang Pei#, Fang Lv#, Xin Niu, Yu You, Liang He, Shijia Hu, Karan M Shah, Mingyao Liu, Yihua Chen, Bing Du*,Hai Xiong*, Jian Luo*, Small molecule JD-312 programs stem cell fate for osteoarthritis treatment, Osteoarthritis and Cartilage, 2023, under review.
21. Waheed Ullah Khan, Muhammad Muzammal Hussain, Farid Ahamd andHai Xiong*, Exploration of the growing trend towards heteroatoms-doped carbon dots based on dopamine acting as a hybrid agent and detected analyte. Dyes and Pigments, 2023, under review.
20. Farid Ahmed, Weiqing Xu, Muhammad Muzammal Hussain, Waheed Ullah Khan andHai Xiong*, Ag+-Mediated Red Fluorescent Carbon Dots Performing to Recognize Cancer Cells from Normal Cells Based on the Bioimaging of Glutathione Detection,2023, submitted.
19. Muhammad Muzammal Hussain, Waheed Ullah Khan, Farid Ahmed, andHai Xiong*, Recent developments of Red/NIR-CDs in biosensing, bioimaging, and tumor theranostics. Chemical Engineering Journal, 2023, 修改稿.
18. Jabrane Jouha, Fengli Li, andHai Xiong*, A Fluorescence Biosensor Based on DNA Aptamers-COF for Highly Selective Detection of ATP and Thrombin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 295, 122615.
17. Weiqing Xu, Farid Ahmed, andHai Xiong*, A mitochondria-targeted fluorescent probe based on biocompatible RBH-U for the enhanced response of Fe3+ in living cells and quenching of Cu2+ in vitro. Analytica Chimica Acta 2023, 1249, 340925.
16. Xue-Yan Yang, Bo Yuan,Hai Xiong*, Yahao Zhao, Lu Wang, San-Qi Zhang,* and Shuai Mao*, Allyl phenyl selenides as H2O2 acceptors to develop ROS-responsive theranostic prodrugs. Bioorganic Chemistry 2022, 129, 106154.
15. Long Zhao, Farid Ahmed, Yating Zeng, Weiqing Xu, andHai Xiong*. Recent Developments in G‑Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes. ACS Sensors 2022, 7, 2833−2856.
14. Farid Ahmed, Shahzad Iqbal, andHai Xiong*, Multifunctional Dual Emissive Fluorescent Probe Based on Europium-doped Carbon Dots (Eu-TCA/NCDs) for Highly Selective Detection of Chloramphenicol, Hg2+ and Fe3+. Environmental Science-Nano 2022, 9, 2624-2637. (正封面文章)
13. Jabrane Jouha, Fengli Li, Wen-Ta Su*, Chenguang Fan*, Dayong Yang*, andHai Xiong*, Editoral: Engineering Nucleic Acids-based Functional Nanomaterials, Nanodrugs, and Biosensors. Frontiers in Bioengineering and Biotechnology 2022, 10, 915229.
12. Shahzad Iqbal, Farid Ahmed, Ziyan Wang, Weiqing Xu, Yating Zeng, andHai Xiong*. Multi-stimuli Responsive Poly(N-isopropyl-co-tetraphenylethene) acrylamide Copolymer Mediating AIEgens by Controllable Tannic Acid. Polymer 2022, 249, 124824.
11. Haixiang Pei, Weikai Guo, Yangrui Peng,Hai Xiong, and Yihua Chen*. Targeting key proteins involved in transcriptional regulation for cancer therapy: Current strategies and future prospective. Medicinal Research Reviews. 2022, 42, 1607–1660.
10. Long Zhao, Farid Ahmed, andHai Xiong*, An excimer ‘ON –OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection. Chinese Chemical Letters 2022, 33, 4243–4247.
9. Jabrane Jouha, andHai Xiong*, DNAzyme-Functionalized nanomaterials: Recent Preparation, Current Applications, and Future Challenges. Small 2021, 17, 2105439. (封面文章)
8. Farid Ahmed, Shahzad Iqbal, Long Zhao, andHai Xiong*, “ON-OFF-ON” fluorescence switches based on N,S-doped carbon dots: Facile hydrothermal growth, selective detection of Hg2+, and as a reversive probe for guanine. Analytica Chimica Acta 2021, 1183, 338977.
7. Shahzad Iqbal, Farid Ahmed, andHai Xiong*, Responsive-DNA hydrogel based intelligent materials: Preparation and applications. Chemical Engineering Journal 2021, 420, 130384.
6. Qiuyun Xiao, Xuan Zhao, andHai Xiong*, Biocompatible and noncytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids. Chinese Chemical Letters 2021, 32, 1687–1690. (正封面文章)
5. Ming-Liang Han, Wei Huang, Yu-Wen Liu, Min Liu, Hui Xu*,Hai Xiong*, and Hui-Xiong Dai*, Pd-Catalyzed Asymmetric Dearomatization of Indoles via Decarbonylative Heck-Type Reaction of Thioesters. Organic Letters 2021, 23, 172−177.
4. Xuan Zhao, Long Zhao, Qiuyun Xiao, andHai Xiong*, Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels. Chinese Chemical Letters 2021, 32, 1363–1366.
3. Farid Ahmed, andHai Xiong*, Recent developments in 1,2,3-triazole-based chemosensors. Dyes and Pigments 2021, 185, 108905.
2. Farid Ahmed, Humaira Kabir, andHai Xiong*, Dual Colorimetric Sensor for Hg2+/Pb2+ and an Efficient Catalyst Based on Silver Nanoparticles Mediating by the Root Extract of Bistorta Amplexicaulis. Frontiers in Chemistry 2020, 8, 591958.
1. Qiuyun Xiao, Zihan Liu, Xuan Zhao, andHai Xiong*, Multiple Site-specific One-Pot Synthesis of Two Proteins by the Bio-orthogonal Flexizyme System. Frontiers in Bioengineering and Biotechnology 2020, 8, 37.
中国专利（2016年-至今）
1.熊海*，肖秋芸，赵烜，“一种蛋白修饰的方法”，中国专利，专利号：2019106243635；申请日：2019.07.11
2.熊海*，赵烜，肖秋芸，“TPE-2’-脱氧核苷、荧光凝胶及其制备方法与应用”，中国专利，专利号：201911244688.7；申请日：2019.12.07
3.熊海*，肖秋芸，赵烜，“一种核酸识别的AIE探针及其制备方法与应用” ，中国专利，专利号：ZL202010830904.2；申请日：2020.08.18. 授权公告号：CN112111267B 授权日：2022.09.30.
4.熊海*，赵龙，“一种芘修饰的G-四链荧光探针及其制备方法与应用”，中国专利，专利号：ZL202110295806.8；申请日：2021.03.19. 授权公告号：CN113087753B 授权日：2022.10.18.
5.熊海*, 李凤丽, Farid Ahmed, “一种稀土配位的氮掺杂碳点双荧光探针及其制备与应用”, 中国专利, 专利号: 202210284234.8；申请日：2022.03.23
6.熊海*, 徐伟清, “一种荧光探针及其制备与应用”, 中国专利, 专利号: 202210932834.0；申请日：2022.08.04
7.熊海*, 李凤丽, Jabrane Jouha, “一种基于共价有机框架材料的适配体荧光传感器及其制备方法与应用”, 中国专利,专利号: 202211683805.1；申请日：2022.12.27
Book-Chapter
SPRINGER NATURE: Book entitled “Metal, Metal-Oxides and Metal Sulfides for Batteries, Fuel Cells, Solar Cells, Photocatalysis and Health Sensors” 2021, ISBN 978-3-030-63791-0 (eBook)
Chapter 8: Developing Trends in DNA Biosensor and Their Applications ---Chandrasekar Selvaraj, Srinivas Bitta Thirumalavenkata andHai Xiong*---
部分发表论文（2004-2016年）
H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme. Angew. Chem. Int. Ed. 2016, 55, 4083-4086.
C. Fan*,H. Xiong, N. Reynolds and D. Söll*, Rationally evolving tRNAPyl for efficient incorporation of noncanonical amino acids. Nucleic Acid Research. 2015, 43(22): e156
H. Xiongand F. Seela*, Cross-Linked DNA: Site Selective “Click” Ligation in Duplexes with Bis-Azides and Stability Changes Caused by Internal Cross-Links. Bioconjugate Chem., 2012, 23, 1230-1243.
H. Xiong, P. Leonard and F. Seela*, Construction and Assembly of Branched Y-shaped DNA: “Click” Chemistry Performed on Dendronized 8-Aza-7-deazaguanine. Oligonucleotides. Bioconjugate Chem., 2012, 23, 856-870.
H. Xiongand F. Seela*, Stepwise “Click” Chemistry for the Template Independent Construction of a Broad Variety of Cross-linked Oligonucleotides: Influence of Linker Length, Position and Linking Number on DNA Duplex Stability. J. Org. Chem., 2011, 76, 5584-5597.
G. Qing,H. Xiong(Co-first authors), F. Seela* and T. Sun*, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites. J. Am. Chem. Soc., 2010, 132, 15228-15232.
H. Xiong, F. Shi, J. Peng and Y. Deng*, Synthesis of supported gold catalysts for selective oxidation of cyclohexane with air. Chin. J. Mol. Catal., 2005, 19(3), 204-207.
H. Xiong, F. Shi and Y. Deng*, Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene. Chin. J. Catal., 2004, 25(11), 887-891.
