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熊海

博士, 研究员(Tenured 副教授)

hai.xiong#szu.edu.cn

致知楼405室

教育背景:

2006-2012年 德国奥斯纳布吕克大学(Osnabrück)和明斯特大学(Münster)纳米技术中心 理学博士

2001-2004年 中科院兰州化学物理研究所 理学硕士

1997-2001年 南昌大学 理学学士


工作经历:

2016-至今深圳大学 研究员

2012-2016年 耶鲁大学 博士后

2004-2006年中科院上海有机化学研究所 研究助理


研究方向:

化学分析与生物传感:化学发光与生物大分子的识别响应

荧光分子探针在肿瘤标志物、重金属离子等方面的识别与应用

生物传感/细胞成像

核酸化学/靶向药物:非天然核酸的化学修饰

核酸适配体-分子靶向药物

核酸纳米自组装的药物控制与释放

材料性能:DNA与微孔材料或金属纳米框架材料之间的界面性能研究

超分子发光材料(COF和MOF)

二维-氧化石墨烯

一维-碳量子点

生物合成:定位装载非天然氨基酸和修饰蛋白的功能团化


所获个人奖励:

2022年 《中国科学:化学》优秀审稿人

2020年 优秀本科教师奖

2018年 广东省珠江人才计划-青年拔尖人才

2017年 深圳市南山区领航人才

2016年 深圳市海外高层次人才(孔雀计划)


学术兼职:

Chinese Chemical Letters:青年编委

Frontiers in Bioengineering and Biotechnology: 专刊客座编辑-Lead Guest Editor

全国研究生教育评估监测专家,国家留学基金评审专家

深圳市生物医药促进会(幽门螺杆菌精准诊疗与健康产业):常务委员

中国感光学会:青年理事

JACS, Analytical Chemistry, ACS Sensors, Sensors and Actuators B-Chemical, Analytica Chimica Acta, ACS AMI,中国科学:化学,Chinese Chemical Letters, Exploration等知名期刊审稿人


科研项目:

1).深圳市海外高层次人才- “孔雀计划”项目,2017/11-2020/12,结题,主持;

2).深圳市科创委基础研究-自由探索项目,2018/04-2020/03,结题,主持;

3).深圳市海外高层次人才创新创业计划-孔雀技术创新项目,2019/03-2021/03,结题,主持;

4).深圳大学青年教师-科研启动项目,2020/01-2022/12,结题,主持;

5).深圳大学与台北科技大学学术合作-专题研究项目,2021/01-2021/12,结题,主持;

6).深圳市科创委基础研究-面上项目,2021/10-2024/10,在研,主持;

7).广东省教育厅广东高校-重点领域专项,2022.01-2024.12,在研,主持;

8).深圳市高校稳定支持计划-面上项目B类,2023.12-2025.11,在研,主持。


目前为止,培养出站+在岗博士后14名,硕士研究生6名,联培博士1+联培硕士4名(其中:多名本科生留学海外知名高校、毕业研究生就职于深圳市属中/小学编制教师、出站博后任职于国企高管或地方高校。发表高水平学术论文近50篇,其中独立通讯/一作的中科院1区论文20多篇(IF ≥ 10的超过10篇)。授权专利3项,联合出版英文专著1部。

He had published nearly 50 articles, such asJ. Am. Chem. Soc., Angew. Chem. Int. Ed.,Coordination Chemistry Reviews.,TrAc-Trends in Anal. Chem., Nucleic Acid Res., Anal. Chem., Chem. Eng. J., Small., ACS Sensors., Org. Lett., Anal. Chim. Acta., Talanta., Chin. Chem. Lett., Environ. Sci: Nano., Journal of Materials Chemistry B., Bioorganic Chem., Dyes and Pigments., Bioconjugate Chem., J. Org. Chem.,etc.


发表论文(独立通讯 / 一作 + 中科院 1 区)

21.Yating Zeng, Ziyan Wang, Linyu Zeng, and Hai Xiong*, Enhancing or Quenching of a Mitochondria-Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+, and Stimulated Response of GSH.Analytic Chemistry, 2023, doi.org/10.1021/acs.analchem.3c04415.

20.Farid Ahmed, Weiqing Xu, Muhammad Muzammal Hussain, Waheed Ullah Khan and Hai Xiong*,Bioimaging-guided Discrimination of Normal/Cancer Cells and Bacteria using Ag+-Mediated Red Fluorescent Carbon Dots.Chemical Engineering Journal, 2023,477, 147300.

19. Hai Xiong*, Fengli Li, Linyu Zeng, and Qiyu Lei, Recent and Emerging Trends of DNA/RNA Hybridized COF Nanoprobes for Analytes Detection and Biomarkers Imaging in Clinical Biomedicines.Trends in Analytical Chemistry, 2024,170, 117414.

18. Yating Zeng, Saima Hameed, Hai Xiong*,Multifunctional nucleoside-AIEgens bearing quaternary ammonium cationic for reversible detection, bioimaging and antibacterial.Analytica Chimica Acta, 2023, 1283, 341924.

17. Farid Ahmed, Muhammad Muzammal Hussain, Waheed Ullah Khan, and Hai Xiong*, Exploring Recent Advancements and Future Prospects on Coordination Self-Assembly of the Regulated Lanthanide-Doped Luminescent Supramolecular Hydrogels.Coordination Chemistry Reviews, 202 4,499, 215486.

16.Waheed Ullah Khan, Muhammad Muzammal Hussain, Farid Ahamd and Hai Xiong*,A review of the growing trend towards heteroatoms-doped carbon dots based on dopamine acting as a hybrid agent and detected analyte.Talanta, 2023, 265, 124781.

15.Muhammad Muzammal Hussain, Waheed Ullah Khan, Farid Ahmed, and Hai Xiong*,Recent developments of Red/NIR-CDs in biosensing, bioimaging, and tumor theranostics.Chemical Engineering Journal, 2023,465, 143010.

14.Weiqing Xu, Farid Ahmed, and Hai Xiong*,A mitochondria-targeted fluorescent probe based on biocompatibleRBH-Ufor theenhanced responseofFe3+in living cells and quenching ofCu2+in vitro.Analytica Chimica Acta, 2023,1249, 340925.

13.Long Zhao, Farid Ahmed, Yating Zeng, Weiqing Xu, and Hai Xiong*,Recent Developments in G‑Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes.ACS Sensors, 2022,7, 2833−2856.

12.Farid Ahmed, Shahzad Iqbal, and Hai Xiong*,Multifunctional Dual Emissive Fluorescent Probe Based on Europium-doped Carbon Dots (Eu-TCA/NCDs) for Highly Selective Detection of Chloramphenicol, Hg2+and Fe3+.Environmental Science-Nano, 2022, 9, 2624-2637.(正封面文章)

11. Long Zhao, Farid Ahmed, and Hai Xiong*,An excimer ‘ON –OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection.Chinese Chemical Letters, 2022,33, 4243–4247.

10.Jabrane Jouha, and Hai Xiong*, DNAzyme-Functionalized nanomaterials: Recent Preparation, Current Applications, and Future Challenges.Small, 2021, 17, 2105439.(封面文章)

9.Farid Ahmed, Shahzad Iqbal, Long Zhao, and Hai Xiong*,“ON-OFF-ON” fluorescence switches based on N,S-doped carbon dots: Facile hydrothermal growth, selective detection of Hg2+, and as a reversive probe for guanine.Analytica Chimica Acta, 2021, 1183, 338977.

8. Shahzad Iqbal, Farid Ahmed, and Hai Xiong*, Responsive-DNA hydrogel based intelligent materials: Preparation and applications.Chemical Engineering Journal, 2021, 420, 130384.

7. Qiuyun Xiao, Xuan Zhao, and Hai Xiong*, Biocompatible and noncytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids.Chinese Chemical Letters, 2021,32, 1687–1690. (正封面文章)

6. Xuan Zhao, Long Zhao, Qiuyun Xiao, and Hai Xiong*, Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels.Chinese Chemical Letters, 2021, 32, 1363–1366.

5. Farid Ahmed, and Hai Xiong*, Recent developments in 1,2,3-triazole-based chemosensors.Dyes and Pigments, 2021, 185, 108905.

4. H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme.Angew. Chem. Int. Ed. 2016,55, 4083-4086.

3.C. Fan*, H. Xiong,N. Reynolds and D. Söll*, Rationally evolving tRNAPylfor efficient incorporation of noncanonical amino acids.Nucleic Acid Research. 2015,43(22):e156

2.G. Qing#, H. Xiong#(Co-first authors), F. Seela* and T. Sun*, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites.J. Am. Chem. Soc., 2010,132, 15228-15232.

1. H. Xiong, F. Shi and Y. Deng*,Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene.Chin. J. Catal., 2004,25(11), 887-891.


授权专利

1. 熊海*,肖秋芸,赵烜,“一种核酸识别的AIE探针及其制备方法与应用”,中国专利,专利号:ZL202010830904.2;申请日:2020.08.18.授权公告号: CN112111267B授权日:2022.09.30.

2. 熊海*,赵龙,“一种芘修饰的G-四链荧光探针及其制备方法与应用”,中国专利,专利号:ZL202110295806.8;申请日:2021.03.19.授权公告号: CN113087753B授权日:2022.10.18.

3. 熊海*,李凤丽, Farid Ahmed, “一种稀土配位的氮掺杂碳点双荧光探针及其制备与应用”,中国专利,专利号:ZL202210284234.8;申请日:2022.03.23.授权公告号: CN 114736671B授权日:2023.07.04.


Book-Chapter

SPRINGER NATURE: Book entitled “Metal, Metal-Oxides and Metal Sulfides for Batteries, Fuel Cells, Solar Cells, Photocatalysis and Health Sensors” 2021,ISBN 978-3-030-63791-0 (eBook)

Chapter 8: Developing Trends in DNA Biosensor and Their Applications---Chandrasekar Selvaraj, Srinivas Bitta Thirumalavenkata and Hai Xiong*---



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