个人网页:http://imet.umces.edu/yli/
教育背景:
2007，香港大学，微藻生物技术，博士
2002，南京大学，生物学，学士
工作经历:
2018- 马里兰大学海洋生物技术研究所，副教授（长聘）
2012-2017 马里兰大学海洋生物技术研究所，助理教授
2009-2012 亚利桑那州立大学，先后担任博士后，研究助理教授
研究兴趣:
微藻生物学，脂类代谢学，代谢工程，微藻能源与生物技术，
学术兼职:
国际海洋生物技术学会，终身会员
美国藻类学会，会员
霍普金斯创新创业俱乐部，科学委员会主席
SCI杂志：Plant Cell, Plant Physiology，Biotechnology and Bioengineering等审稿人
近期会议报告:
2017. 10，美国植物学会秋季会议，巴尔的摩，美国。特邀报告人
报告题目: A Prokaryotic Pathway for Triacylglycerol Biosynthesis in Microalgae.
2016. 9，国际海洋生物技术学会年会，巴尔的摩，美国。特邀主题报告人和海洋生物能源和生物技术论坛主席
报告题目: Fit or Fat: The Molecular Mechanism and Bioenergy Implications of Triacylglycerol (TAG) Biosynthesis in Microalgae.
2016. 9，亚太藻类峰会年会，武汉，中国。特邀报告人
报告题目: Fit or Fat: The Molecular Mechanism and Bioenergy Implications of Triacylglycerol (TAG) Biosynthesis in Microalgae.
论文发表:
1Xin, Y., 1Lu, Y., 1Lee, Y.-Y., Wei, L., Jia, J., Wang, Q., Wang, D., Bai, F., Hu, H.,Hu, Q., 2Liu, J., 2Li, Y. and 2Xu, J. (2017) Producing designer oils in industrial microalgae by rational modulation of co-evolving type-2 diacylglycerol acyltransferases. Molecular Plant, 10, 1523-1539. (1co-first authors; 2co-corresponding authors)
Wei HH, Shi Y, Ma XN, Pan Y, Hu HH, Li YT, Luo M, Gerken H, Liu J (2017) A type I diacylglycerol acyltransferase modulates triacylglycerol biosynthesis and fatty acid composition in the oleaginous microalga Nannochloropsis oceanica. Biotechnology for Biofuels, 10: 174
Wang Y, Lee Y-Y, Santaus TM, Newcomb CE, Liu J, Geddes CD, *Zhang C, Hu Q, *Li Y (2017) In situ enzymatic conversion of Nannochloropsis oceanica IMET1 biomass into fatty acid methyl esters. BioEnergy Research. 10:438-448
*Liu J, Lee YY, Mao X, and *Li YT (2017) A simple and reproducible non-radiolabeled in vitro assay for recombinant acyltransferases involved in triacylglycerol biosynthesis. J. Appl. Phycol. 29:323-333
Lenka SK, Carbonaro N, Park R, Miller SK, Thorpe I, Li YT. (2016) Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis. Biotechnology Advance. 34: 1046-1063.
Liu J, Han D, Yoon K, *Hu Q, *Li YT (2016) Characterization of type 2 diacylglycerol acyltransferases in Chlamydomonas reinhardtii reveals their distinct substrate specificities and functions in triacylglycerol biosynthesis. Plant Journal 86, 3-19. (Cover story and featured article)
Jia J, Han DX, Gerken H, Li YT, Sommerfeld M, Hu Q, Xu J (2015) Molecular mechanisms for photosynthetic carbon partitioning into storage neutral lipids in Nannochloropsis oceanica under nitrogen-depletion conditions. Algal Research 7, 66-77.
Wang Y, Liu J, Gerken H, Zhang CW, Hu Q, Li YT (2014) Highly-efficient enzymatic conversion of crude algal oils into biodiesel. Bioresour. Technol. 172, 143-149.
Li J, Han DX, Wang D, Ning K, Jia J, Wei L, Jing X, Huang S, Chen J, Li YT, Hu Q, Xu J (2014) Choreography of transcriptomes and lipidomes in Nannochloropsis reveals the mechanisms of oleaginousness in microalgae. Plant Cell 26: 1645-1665. (ISI Web of Science Highly cited article)
*Liu J, Gerken H, *Li Y (2014) Single-tube colony PCR for DNA amplification and transformant screening of oleaginous microalgae. J. Appl. Phycol. 26: 1719-1726
Han DX1, Li YT1, Hu Q (2013) Astaxanthin in microalgae: pathways, functions and biotechnological implications. Algae 28: 131-147 (1Equal contribution)
Yoon K, Han D, Li Y, Sommerfeld M, Hu Q (2012) Phospholipid:diacylglycerol acyltransferase is a multifunctional enzyme involved in membrane lipid turnover and degradation while synthesizing triacylglycerol in the unicellular green microalga Chlamydomonas reinhardtii. Plant Cell 24: 3708-3724 (Highly cited article)
Li Y, Han D, Sommerfeld M, Hu Q (2011) Photosynthetic carbon partitioning and lipid production in the oleaginous microalga Pseudochlorococcum sp. (Chlorophyceae) under nitrogen-limited conditions. Bioresour. Technol. 102: 123-129
Packer A, Li YT, Andersen T, Hu QA, Kuang Y, Sommerfeld M (2011) Growth and neutral lipid synthesis in green microalgae: A mathematical model. Bioresour. Technol. 102: 111-117
Li Y, Han D, Hu G, Dauvillee D, Sommerfeld M, Ball S, Hu Q (2010) Chlamydomonas starchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol. Metabolic Engineering 12: 387-391 (Highly cited article)
Li Y, Han D, Hu G, Sommerfeld M, Hu Q (2010) Inhibition of starch synthesis results in overproduction of lipids in Chlamydomonas reinhardtii. Biotechnol. Bioeng. 107: 258-268 (Highly accessed article)
Li Y, Sommerfeld M, Chen F, Hu Q (2010) Effect of photon flux densities on regulation of carotenogenesis and cell viability of Haematococcus pluvialis (Chlorophyceae). J. Appl. Phycol. 22: 253-263
Li Y, Huang J, Sandmann G, Chen F (2009) High-light and sodium chloride stress differentially regulate the biosynthesis of astaxanthin in Chlorella zofingiensis (Chlorophyceae). J. Phycol. 45: 635-641
Hu Z, Li Y, Sommerfeld M, Hu Q (2008) Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae). Eur. J. Phycol. 43: 365-376
Huang JC, Liu J, Li YT, Chen F (2008) Isolation and characterization of the phytoene desaturase gene as a potential selective marker for genetic engineering of the astaxanthin-producing green alga Chlorella zofingiensis (Chlorophyta). J. Phycol. 44: 684-690
Li Y, Huang J, Sandmann G, Chen F (2008) Glucose sensing and the mitochondrial alternative pathway are involved in the regulation of astaxanthin biosynthesis in the dark-grown Chlorella zofingiensis (Chlorophyceae). Planta 228: 735-743
Li Y, Sommerfeld M, Chen F, Hu Q (2008) Consumption of oxygen by astaxanthin biosynthesis: A protective mechanism against oxidative stress in Haematococcus pluvialis (Chlorophyceae). J Plant Physiol 165:1783-97 (Highly accessed article)
Sun N, Wang Y, Li YT,Huang JC, Chen F (2008) Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta). Process Biochem. 43: 1288-1292
1Xin, Y., 1Lu, Y., 1Lee, Y.-Y., Wei, L., Jia, J., Wang, Q., Wang, D., Bai, F., Hu, H.,Hu, Q., 2Liu, J., 2Li, Y. and 2Xu, J. (2017) Producing designer oils in industrial microalgae by rational modulation of co-evolving type-2 diacylglycerol acyltransferases. Molecular Plant, 10, 1523-1539. (1co-first authors; 2co-corresponding authors)
Wei HH, Shi Y, Ma XN, Pan Y, Hu HH, Li YT, Luo M, Gerken H, Liu J (2017) A type I diacylglycerol acyltransferase modulates triacylglycerol biosynthesis and fatty acid composition in the oleaginous microalga Nannochloropsis oceanica. Biotechnology for Biofuels, 10: 174
Wang Y, Lee Y-Y, Santaus TM, Newcomb CE, Liu J, Geddes CD, *Zhang C, Hu Q, *Li Y (2017) In situ enzymatic conversion of Nannochloropsis oceanica IMET1 biomass into fatty acid methyl esters. BioEnergy Research. 10:438-448
*Liu J, Lee YY, Mao X, and *Li YT (2017) A simple and reproducible non-radiolabeled in vitro assay for recombinant acyltransferases involved in triacylglycerol biosynthesis. J. Appl. Phycol. 29:323-333
Lenka SK, Carbonaro N, Park R, Miller SK, Thorpe I, Li YT. (2016) Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis. Biotechnology Advance. 34: 1046-1063.
Liu J, Han D, Yoon K, *Hu Q, *Li YT (2016) Characterization of type 2 diacylglycerol acyltransferases in Chlamydomonas reinhardtii reveals their distinct substrate specificities and functions in triacylglycerol biosynthesis. Plant Journal 86, 3-19. (Cover story and featured article)
Jia J, Han DX, Gerken H, Li YT, Sommerfeld M, Hu Q, Xu J (2015) Molecular mechanisms for photosynthetic carbon partitioning into storage neutral lipids in Nannochloropsis oceanica under nitrogen-depletion conditions. Algal Research 7, 66-77.
Wang Y, Liu J, Gerken H, Zhang CW, Hu Q, Li YT (2014) Highly-efficient enzymatic conversion of crude algal oils into biodiesel. Bioresour. Technol. 172, 143-149.
Li J, Han DX, Wang D, Ning K, Jia J, Wei L, Jing X, Huang S, Chen J, Li YT, Hu Q, Xu J (2014) Choreography of transcriptomes and lipidomes in Nannochloropsis reveals the mechanisms of oleaginousness in microalgae. Plant Cell 26: 1645-1665. (ISI Web of Science Highly cited article)
*Liu J, Gerken H, *Li Y (2014) Single-tube colony PCR for DNA amplification and transformant screening of oleaginous microalgae. J. Appl. Phycol. 26: 1719-1726
Han DX1, Li YT1, Hu Q (2013) Astaxanthin in microalgae: pathways, functions and biotechnological implications. Algae 28: 131-147 (1Equal contribution)
Yoon K, Han D, Li Y, Sommerfeld M, Hu Q (2012) Phospholipid:diacylglycerol acyltransferase is a multifunctional enzyme involved in membrane lipid turnover and degradation while synthesizing triacylglycerol in the unicellular green microalga Chlamydomonas reinhardtii. Plant Cell 24: 3708-3724 (Highly cited article)
Li Y, Han D, Sommerfeld M, Hu Q (2011) Photosynthetic carbon partitioning and lipid production in the oleaginous microalga Pseudochlorococcum sp. (Chlorophyceae) under nitrogen-limited conditions. Bioresour. Technol. 102: 123-129
Packer A, Li YT, Andersen T, Hu QA, Kuang Y, Sommerfeld M (2011) Growth and neutral lipid synthesis in green microalgae: A mathematical model. Bioresour. Technol. 102: 111-117
Li Y, Han D, Hu G, Dauvillee D, Sommerfeld M, Ball S, Hu Q (2010) Chlamydomonas starchless mutant defective in ADP-glucose pyrophosphorylase hyper-accumulates triacylglycerol. Metabolic Engineering 12: 387-391 (Highly cited article)
Li Y, Han D, Hu G, Sommerfeld M, Hu Q (2010) Inhibition of starch synthesis results in overproduction of lipids in Chlamydomonas reinhardtii. Biotechnol. Bioeng. 107: 258-268 (Highly accessed article)
Li Y, Sommerfeld M, Chen F, Hu Q (2010) Effect of photon flux densities on regulation of carotenogenesis and cell viability of Haematococcus pluvialis (Chlorophyceae). J. Appl. Phycol. 22: 253-263
Li Y, Huang J, Sandmann G, Chen F (2009) High-light and sodium chloride stress differentially regulate the biosynthesis of astaxanthin in Chlorella zofingiensis (Chlorophyceae). J. Phycol. 45: 635-641
Hu Z, Li Y, Sommerfeld M, Hu Q (2008) Enhanced protection against oxidative stress in an astaxanthin-overproduction Haematococcus mutant (Chlorophyceae). Eur. J. Phycol. 43: 365-376
Huang JC, Liu J, Li YT, Chen F (2008) Isolation and characterization of the phytoene desaturase gene as a potential selective marker for genetic engineering of the astaxanthin-producing green alga Chlorella zofingiensis (Chlorophyta). J. Phycol. 44: 684-690
Li Y, Huang J, Sandmann G, Chen F (2008) Glucose sensing and the mitochondrial alternative pathway are involved in the regulation of astaxanthin biosynthesis in the dark-grown Chlorella zofingiensis (Chlorophyceae). Planta 228: 735-743
Li Y, Sommerfeld M, Chen F, Hu Q (2008) Consumption of oxygen by astaxanthin biosynthesis: A protective mechanism against oxidative stress in Haematococcus pluvialis (Chlorophyceae). J Plant Physiol 165:1783-97 (Highly accessed article)
Sun N, Wang Y, Li YT,Huang JC, Chen F (2008) Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta). Process Biochem. 43: 1288-1292
