教育背景:
2006-2012年 德国奥斯纳布吕克大学(Osnabrück)和明斯特大学(Münster)纳米技术中心 理学博士
2001-2004年 中科院兰州化学物理研究所 理学硕士
1997-2001年 南昌大学 理学学士
工作经历:
2016-至今深圳大学 研究员
2012-2016年 耶鲁大学 博士后
2004-2006年 中科院上海有机化学研究所 研究助理
研究方向:
分析化学与传感:化学发光与肿瘤标志物/环境分析物的识别响应
荧光探针/化学传感
生物传感/细胞成像
生物有机化学/靶向药物化学:非天然核酸的化学修饰
化学合成
核酸适配体-分子靶向药物
核酸纳米自组装的药物控制与释放
材料合成和表界面化学:DNA与微孔材料或金属纳米框架材料之间的界面性能研究
超分子发光材料(COF和MOF)
二维-氧化石墨烯
一维-碳量子点
生物合成化学:定位装载非天然氨基酸和修饰蛋白的功能团化
所获个人奖励:
2018年 广东省珠江人才计划-青年拔尖人才
2017年 深圳市南山区领航人才
2016年 深圳市海外高层次人才(孔雀计划)
学术兼职和社会服务:
Chinese Chemical Letters:青年编委
Frontiers in Bioengineering and Biotechnology:专刊客座编辑-Lead Guest Editor
全国研究生教育评估监测专家,国家留学基金评审专家
深圳市生物医药促进会(幽门螺杆菌精准诊疗与健康产业): 常务委员
中国感光学会第一届青年理事会:青年理事
JACS,Analytical Chemistry, ACS Sensors, Sensors and Actuators B-Chemical, Analytica Chimica Acta, ACS AMI,Bioconjugate Chemistry,中国科学:化学, Chinese Chemical Letters, Exploration等知名期刊审稿人
2017年,深圳大学工会---工作积极分子
2018年,深圳大学高等研究院---第一期暑期夏令营(组织/负责人)
2018年,深圳大学高等研究院交叉学科论坛---第三期智能材料(组织/负责人)
2018-2023年度,深圳大学教代会---教师代表
2019-2020年,教学单项奖(优秀本科教师奖)
2022年,《中国科学:化学》优秀审稿人
2023-2024年度,深圳大学高等研究院---优秀党员
科研项目:
1).深圳市海外高层次人才-“孔雀计划”项目,2017/11-2020/12,结题,主持;
2).深圳市科创委基础研究-自由探索项目,2018/04-2020/03,结题,主持;
3).深圳市海外高层次人才创新创业计划-孔雀技术创新项目,2019/03-2021/03,结题,主持;
4).深圳大学青年教师-科研启动项目,2020/01-2022/12,结题,主持;
5).深圳大学与台北科技大学学术合作-专题研究项目,2021/01-2021/12,结题,主持;
6).深圳市科创委基础研究-面上项目,2021/10-2024/10,在研,主持;
7).广东省教育厅广东高校-重点领域专项,2022.01-2024.12,在研,主持;
8).深圳市高校稳定支持计划-面上项目B类,2023.12-2025.11,在研,主持;
9).深圳大学本科教学改革研究项目,2024.09-2025.08,在研,主持;
10).深圳大学研究生招生联络单位建设项目-云南大学, 2024.09-2017.08,在研,主持。
培养出站+在岗博士后14名,硕士研究生6名,联培博士1名+联培硕士4名(其中:指导多名本科生获得大学生创新项目---省级立项, 多名本科生留学海外知名高校、多名研究生毕业后就职于深圳市属中/小学编制教师,培养的博后出站后任职于国企高管或地方院校)。发表高水平学术论文近50篇,其中独立通讯/一作的中科院1区论文20多篇(IF≥10的超过10篇)。授权专利5项,联合出版英文专著1部。
He had published nearly 50 articles, such asJ. Am. Chem. Soc., Angew. Chem. Int. Ed.,Coordination Chemistry Reviews.,TrAc-Trends in Anal. Chem., Nucleic Acid Res.,Anal.Chem., Chem. Eng. J., Small., ACS Sensors.,Bioactive Materials.,Org. Lett., Anal. Chim. Acta., Talanta.,Chin. Chem. Lett., Environ. Sci: Nano., Journal of Materials Chemistry B., Bioorganic Chem., Dyes and Pigments., Bioconjugate Chem., J. Org. Chem.,etc.
发表论文(独立通讯/一作,且为中科院一区)
21.Saima Hameed,Sumaira Sharif, Muhammad Ovais,and Hai Xiong*,Emerging Trends andFutureChallengesofAdvanced 2D Nanomaterials for Combating Bacterial Resistance. Bioactive Materials , 2024 ,38, 225–257.
20.Yating Zeng, Ziyan Wang, Linyu Zeng, and Hai Xiong*, Enhancing or Quenching of a Mitochondria-Targeted AIEgens-Floxuridine Sensor by the Regulation of pH-Dependent Self-assembly, Efficient Recognition of Hg2+, and Stimulated Response of GSH. Analytic Chemistry , 2023 , 95, 18880−18888.
19.Farid Ahmed, Weiqing Xu, Muhammad Muzammal Hussain, Waheed Ullah Khan and Hai Xiong*,Bioimaging-guided Discrimination of Normal/Cancer Cells and Bacteria using Ag+-Mediated Red Fluorescent Carbon Dots. Chemical Engineering Journal , 2023 ,477, 147300.
18. Hai Xiong*,Fengli Li, Linyu Zeng, and Qiyu Lei, Recent and Emerging Trends of DNA/RNA Hybridized COF Nanoprobes for Analytes Detection and Biomarkers Imaging in Clinical Biomedicines. Trends in Analytical Chemistry , 2024 ,170, 117414.
17.Yating Zeng, Saima Hameed, Hai Xiong*,Multifunctional nucleoside-AIEgensbearingquaternary ammonium cationic for reversible detection, bioimaging and antibacterial. Analytica Chimica Acta , 2023 , 1283, 341924.
16. Farid Ahmed, Muhammad Muzammal Hussain, Waheed Ullah Khan, and Hai Xiong*, Exploring Recent Advancements and Future Prospects on Coordination Self-Assembly of the Regulated Lanthanide-Doped Luminescent Supramolecular Hydrogels. Coordination Chemistry Reviews , 202 4 ,499, 215486.
15.Waheed Ullah Khan, Muhammad Muzammal Hussain, Farid Ahamd and Hai Xiong*,A review of the growing trend towards heteroatoms-doped carbon dots based on dopamine acting as a hybrid agent and detected analyte. Talanta , 2023 , 265, 124781.
14.Muhammad Muzammal Hussain, Waheed Ullah Khan, Farid Ahmed, and Hai Xiong*,Recent developments of Red/NIR-CDs in biosensing, bioimaging, and tumor theranostics. Chemical Engineering Journal , 2023 , 465, 143010.
13.Weiqing Xu, Farid Ahmed, and Hai Xiong*,A mitochondria-targeted fluorescent probe based on biocompatibleRBH-Ufor theenhanced responseofFe3+in living cells and quenching ofCu2+in vitro. Analytica Chimica Acta , 2023 ,1249, 340925.
12.Long Zhao, Farid Ahmed, Yating Zeng, Weiqing Xu, and Hai Xiong*,Recent Developments in G‑Quadruplex Binding Ligands and Specific Beacons on Smart Fluorescent Sensor for Targeting Metal Ions and Biological Analytes. ACS Sensors, 2022 , 7, 2833−2856.
11.Farid Ahmed, Shahzad Iqbal, and Hai Xiong*,Multifunctional Dual Emissive Fluorescent ProbeBased on Europium-doped Carbon Dots (Eu-TCA/NCDs) for HighlySelectiveDetection of Chloramphenicol, Hg2+and Fe3+. Environmental Science-Nano , 2022 ,9, 2624-2637.(正封面文章)
10.Long Zhao, Farid Ahmed, and Hai Xiong*,An excimer ‘ON –OFF’ switch based on telomeric G-quadruplex and rGO for trace thrombin detection. Chinese Chemical Letters , 2022 ,33, 4243–4247.
9.Jabrane Jouha, and Hai Xiong*, DNAzyme-Functionalized nanomaterials: Recent Preparation, Current Applications, and Future Challenges. Small , 2021 ,17,2105439.(封面文章)
8.Farid Ahmed, Shahzad Iqbal, Long Zhao, and Hai Xiong*,“ON-OFF-ON” fluorescence switches based on N,S-doped carbon dots: Facile hydrothermal growth, selective detection of Hg2+, and as a reversive probe for guanine. Analytica Chimica Acta , 2021, 1183, 338977.
7. Shahzad Iqbal, Farid Ahmed, and Hai Xiong*, Responsive-DNA hydrogel based intelligent materials: Preparation and applications. Chemical Engineering Journal , 2021, 420, 130384.
6. Qiuyun Xiao, Xuan Zhao, and Hai Xiong*, Biocompatible and noncytotoxic nucleoside-based AIEgens sensor for lighting-up nucleic acids. Chinese Chemical Letters , 2021 ,32, 1687–1690. (正封面文章)
5. Xuan Zhao, Long Zhao, Qiuyun Xiao, and Hai Xiong*, Intermolecular hydrogen-bond interaction to promote thermoreversible 2'-deoxyuridine-based AIE-organogels. Chinese Chemical Letters , 2021 , 32, 1363–1366.
4. Farid Ahmed, and Hai Xiong*, Recent developments in 1,2,3-triazole-based chemosensors. Dyes and Pigments , 2021 , 185, 108905.
3. H. Xiong, N. Reynolds, C. Fan, M. Englert, D. Hoyer, S. Miller and D. Söll*, Dual Genetic Encoding of Acetyl-lysine and Non-deacetylatable Thioacetyl-lysine Mediated by Flexizyme. Angew. Chem. Int. Ed. 2016 ,55, 4083-4086.
2.G. Qing#, H. Xiong# (Co-first authors), F. Seela* and T. Sun*, Spatially Controlled DNA Nano-patterns by “Click” Chemistry Using Oligonucleotides with Different Anchoring Sites. J. Am. Chem. Soc. , 2010 , 132 , 15228-15232.
1. H. Xiong, F. Shi and Y. Deng*,Synthesis and application of supported cobalt catalyst for selective oxidation of cyclohexane and toluene. Chin. J. Catal. , 2004 , 25 (11), 887-891.
授权专利
1.熊海*,肖秋芸,赵烜,“一种核酸识别的AIE探针及其制备方法与应用”,中国专利,专利号:ZL202010830904.2;申请日:2020.08.18.授权公告号:CN112111267B授权日:2022.09.30.
2.熊海*,赵龙,“一种芘修饰的G-四链荧光探针及其制备方法与应用”,中国专利,专利号:ZL202110295806.8;申请日:2021.03.19.授权公告号:CN113087753B授权日:2022.10.18.
3.熊海*,李凤丽, Farid Ahmed, “一种稀土配位的氮掺杂碳点双荧光探针及其制备与应用”,中国专利,专利号:ZL202210284234.8;申请日:2022.03.23.授权公告号:CN 114736671B 授权日:2023.07.04.
4.熊海*,徐伟清,Waheed Ullah Khan,“一种氮掺杂碳量子点探针及其制备方法与应用”,中国专利,专利号: 202410505937.8;申请日:2023.07.14.授权公告号:CN116925754B 授权日:2024.05.17.
5.熊海*,徐伟清, “一种荧光探针及其制备与应用”,中国专利,专利号:202210932834.0;申请日:2022.08.04.授权公告号:CN115353538B 授权日:2024.08.23.
Book-Chapter
SPRINGER NATURE: Book entitled “Metal,Metal-Oxides andMetalSulfides forBatteries,FuelCells,SolarCells, Photocatalysis and Health Sensors”2021,ISBN 978-3-030-63791-0 (eBook)
Chapter 8:Developing Trends in DNA Biosensor and Their Applications---Chandrasekar Selvaraj, Srinivas Bitta Thirumalavenkata andHai Xiong*---