ResearchGate: https://www.researchgate.net/profile/Xinxu-Zhang/research

Google Scholar: https://scholar.google.com/citations?user=Uw2W7LUAAAAJ&hl=en

课题组主页：https://www.x-mol.com/groups/mi

教育背景：

2010.09-2016.03，上海交通大学，博士，生物学

2014.03-2014.09，美国南加州大学，访问学者，微生物学

2006.09-2010.06，南京农业大学，学士，生物技术

工作经历：

2023.03至今，研究员，深圳大学高等研究院

2018.03-2023.02，副研究员，深圳大学高等研究院

2016.04-2018.02，博士后，汕头大学海洋生物研究所

研究兴趣：

1. 海洋深部生物圈

2. 水生无脊椎动物免疫

科研项目：

1. 微生物调控海洋沉积物甲烷通量的机制研究—以波罗的海为例. 2025.01-2028.12. 国家自然科学基金面上项目. 主持. 48万元.

2. 深渊海沟沉积物中古菌群落的生态分布特点及其碳氮代谢机制研究—以雅浦海沟为例. 2020.01-2022.12. 国家自然科学基金重大研究计划培育项目. 主持. 79万元.

3. 拟穴青蟹血淋巴共生微生物菌群的代谢功能多样性研究. 2018.01-2020.12. 国家自然科学基金青年科学基金项目. 主持. 25万元.

4. 血淋巴菌群介导的拟穴青蟹先天性免疫应答机制研究. 2025.01-2027.12. 广东省基础与应用基础研究基金面上项目. 主持. 10万元.

5. 拟穴青蟹的微生物组及血淋巴微生物的代谢潜能研究. 2017.01-2018.02. 中国博士后科学基金面上项目二等资助. 主持. 5万元.

6. 虾蟹血淋巴中的抗菌肽与其共生菌群的互作机制研究. 2020.05-2023.05. 深圳市基础研究面上项目. 主持. 30万元.

7. 华贵栉孔扇贝“南澳金贝”体内微生物组参与宿主类胡萝卜素积累的机制研究. 2019.03-2021.03. 深圳市基础研究自由探索项目. 主持. 30万元.

发表论文 (^#第一作者. ^*通讯作者)

2022-2025：

1. Rathour R., Ma Y., Xiong J., Wang X., Petersen Jillian^*, Zhang Xinxu^*. Hemolymph microbiota and host immunity of crustaceans and mollusks. ISME J., 2025, wraf133.

2. Yan J.^#, Zhang Xinxu^#, Shi X., Wu J., Zhou Z., Tang Y., Bao Z., Luo N., Zhang Demin^*, Chen J., Zhang Huajun^*. Metagenomic insights into the rapid recovery mechanisms of prokaryotic community and spread of antibiotic resistance genes after seawater disinfection. Water Res., 2025, 271:122887.

3. Sha H., Zhang Xinxu, Chen J., Qiu Q., Xiong Jinbo^*. Prophylactic sarafloxacin hydrochloride increases shrimp susceptibility to AHPND via transferring antibiotic resistance genes and virulence factors. Aquaculture, 2025, 603:742379.

4. Huang Y.^#, Zhang Xinxu^#, Xin Y., Tian J., Li Meng^*. Distinct microbial nitrogen cycling processes in the deepest part of the ocean. mSystems, 2024, 9:e00243-24.

5. Sha H., Song T., Zhan P., Zhang Xinxu, Chen, J., Xiong Jinbo^*. Sarafloxacin hydrochloride exposure disrupts gut microbiota and increases shrimp susceptibility to Vibrio anguillarum infection. Aquaculture, 2024, 586:740810.

6. Zhang Xinxu, Zhang C., Liu Y., Zhang R., Li Meng^*. Non-negligible roles of archaea in coastal carbon biogeochemical cycling. Trends Microbiol., 2023, 31:586-600.

7. Pan J., Zhang Xinxu, Xu W., Liu Y., Liu L., Luo Z., Li Meng^*. Wood-Ljungdahl pathway found in novel marine Korarchaeota groups illuminates their evolutionary history. mSystems, 2023, 8: e00305-23.

8. Zhang Xinxu, Huang Y., Liu Y., Xu W., Pan J., Zheng X., Du H., Zhang C., Lu Z., Zou D., Liu Z., Cai M., Xiong J., Zhu Y., Dong Z., Jiang H., Dong H., Jiang J., Luo Z., Huang L., Li Meng^*. An ancient respiratory system in the widespread sedimentary archaea Thermoprofundales. Mol. Biol. Evol., 2022, 39:msac213.

9. Zhang Xinxu^#, Liu Z.^#, Xu W., Pan J., Huang Y., Cai M., Luo Z., Li Meng^*. Genomic insights into versatile lifestyle of three new bacterial candidate phyla. Sci. China Life Sci., 2022, 65: 1547-1562.

10. Cai M.^#, Duan C.^#, Zhang Xinxu, Pan J., Liu Y., Zhang C., Li Meng^*. Genomic and transcriptomic dissection of Theionarchaea in marine ecosystem. Sci. China Life Sci., 2022, 65:1222-34.

2018-2021：

11. Zhang M.^#, Zhang Xinxu^#, Tran N., Sun Z., Zhang X., Ye H., Zhang Y., Ma H., Aweya J., Li Shengkang^*. Molting alters the microbiome, immune response, and digestive enzyme activity in mud crab (Scylla paramamosain). mSystems, 2021, 6:e00917-21.

12. Lu J.^#, Zhang Xinxu^#, Wang C., Li M., Chen J., Xiong Jinbo^*. Responses of sediment resistome, virulence factors and potential pathogens to decades of antibiotics pollution in a shrimp aquafarm. Sci. Total Environ., 2021, 794:148760.

13. Liu Y.^#, Makarova K.^#, Huang W.^#, Wolf Y., Nikolskaya A., Zhang Xinxu, Cai M., Zhang C., Xu W., Luo Z., Cheng Lei^*, Koonin Eugene^*, Li Meng^*. Expanded diversity of Asgard archaea and their relationships with eukaryotes. Nature, 2021, 593:553-57.

14. Huang W.^#, Liu Y.^#, Zhang Xinxu, Zhang C., Zou D., Zheng S., Xu W., Luo Z., Liu F., Li Meng^*. Comparative genomic analysis reveals metabolic flexibility of Woesearchaeota. Nat. Commun., 2021, 12:5281.

15. Zhang Xinxu^#, Zhang M.^#, Zheng H., Ye H., Zhang X., Li Shengkang^*. Source of hemolymph microbiota and their roles in the immune system of mud crab. Dev. Comp. Immunol., 2020, 102:103470.

16. 张新旭, 李猛^*. 海洋沉积物中几类常见古菌类群的分布与代谢特征. 微生物学报, 2020, 60:1907-21.

17. Qin Wei^#,*, Zheng Y.^#, Zhao Feng^*, Wang Y., Urakawa, H., Martens-Habbena, W., Liu H., Huang X., Zhang Xinxu, Nakagawa T., Mende D., Bollmann A., Wang B., Zhang Y., Amin S., Nielsen J., Mori K., Takahashi R., Virginia Armbrust E.W., Winkler Mari-K.H., DeLong E., Li M., Lee P., Zhou J., Zhang C., Zhang T., Stahl, D., Ingalls Anitra^*. Alternative strategies of nutrient acquisition and energy conservation map to the biogeography of marine ammonia-oxidizing archaea. ISME J., 2020, 14:2595-2609.

18. Liu H., Zhang C., Zhang Xinxu, Tan K., Zhang H., Cheng D.,Ye T., Li S., Ma H., Zheng Huaiping^*. A novel carotenoids-producing marine bacterium from noble scallop Chlamys nobilis and antioxidant activities of its carotenoid compositions. Food Chem., 2020, 320:126629.

19. Cheng D., Zhang H., Liu H., Zhang Xinxu, Tan K., Li S., Ma H., Zheng Huaiping^*. Identification and molecular characterization of peroxiredoxin 6 from noble scallop Chlamys nobilis revealing its potent immune response and antioxidant property. Fish Shellfish Immunol., 2020, 100:368-377.

20. Liu H., Tan K., Zhang Xinxu, Zhang H., Cheng D., Ye T., Li S., Ma H., Zheng Huaiping^*. Comparison of gut microbiota between golden and brown noble scallop Chlamys nobilis and its association with carotenoids. Front. Microbiol., 2020, 11:36.

21. Gao Y., Du X., Xu W., Fan R., Zhang Xinxu, Yang S., Chen X., Lv J., Luo Zhuhua^*. Fungal diversity in deep sea sediments from east Yap Trench and their denitrification potential. Geomicrobiol. J., 2020, 37:848-58.

22. Wang Y., Zhang Xinxu, Wang J., Xiao X., Wang Fengping^*. Genomic analysis of Marinobacter sp. NP-4 and NP-6 isolated from the deep-sea oceanic crust on the western flank of the Mid-Atlantic Ridge. Mar. Genom., 2020, 50:100693.

23. Li Z., Zhang Xinxu, Aweya J., Wang S., Hu Z., Li Shengkang^*, Wen X. Formulated diet alters gut microbiota compositions in marine fish Nibea coibor and Nibea diacanthus. Aquac. Res., 2019, 50:126-138.

24. Zhang Xinxu, Sun Z., Zhang X., Zhang M., Li Shengkang^*. Hemolymph microbiomes of three aquatic invertebrates as revealed by a new cell extraction method. Appl. Environ. Microbiol., 2018, 84:e02824-17.

25. Wei X.^#, Wang L.^#, Sun W., Zhang M., Ma H., Zhang Y., Zhang Xinxu^*, Li Shengkang^*. C-type lectin B (SpCTL-B) regulates the expression of antimicrobial peptides and promotes phagocytosis in mud crab Scylla paramamosain. Dev. Comp. Immunol., 2018, 84:213-229.

26. Zhang Xinxu^#, Xu W.^#, Liu Y., Cai M., Luo Zhuhua^*, Li Meng^*. Metagenomics reveals microbial diversity and metabolic potentials of seawater and surface sediment from a hadal biosphere at the Yap Trench. Front. Microbiol., 2018, 9:2402.

27. Reese Brandi^*, Zinke L., Sobol M., LaRowe D., Orcutt B., Zhang Xinxu, Jaekel U., Wang F., Dittmar T., Defforey D., Tully B., Paytan A., Sylvan J., Amend J., Edwards K., Girguis P. Nitrogen cycling of active bacteria within oligotrophic sediment of the Mid-Atlantic Ridge flank. Geomicrobiol. J., 2018, 35:468-83.

2013-2017：

28. Zhang Xinxu, Wu H., Li Z., Li Y., Wang S., Zhu D., Wen X., Li Shengkang^*. Effects of dietary supplementation of Ulva pertusa and non-starch polysaccharide enzymes on gut microbiota of Siganus canaliculatus. J. Oceanol. Limnol., 2017, 36:438-49.

29. Sun W., Zhang Xinxu, Wan W., Wang S., Wen X., Zheng H., Zhang Y., Li Shengkang^*. Tumor necrosis factor receptor-associated factor 6 (TRAF6) participates in anti-lipopolysaccharide factors (ALFs) gene expression in mud crab. Dev. Comp. Immunol., 2017, 67:361-376.

30. Zhang Xinxu, Feng X., Wang Fengping^*. Diversity and metabolic potentials of subsurface crustal microorganisms from the western flank of the Mid-Atlantic Ridge. Front. Microbiol., 2016, 7:363.

31. Zhang Xinxu, Fang J., Bach W., Edwards K., Orcutt B., Wang Fengping^*. Nitrogen stimulates the growth of subsurface basalt-associated microorganisms at the western flank of the Mid-Atlantic Ridge. Front. Microbiol., 2016, 7:633.

32. Natarajan V. P.^#, Zhang Xinxu^#, Morono Y., Inagaki F., Wang Fengping^*. A modified SDS-based DNA extraction method for high quality environmental DNA from seafloor environments. Front. Microbiol., 2016, 7:986.

33. Wang Fengping^#,*, Zhang Y.^#, Chen Y., He Y., Qi J., Hinrichs K., Zhang Xinxu, Xiao Xiang^*, Boon N. Methanotrophic archaea possessing diverging methane-oxidizing and electron-transporting pathways. ISME J., 2014, 8:1069-78.

34. 王风平, 周悦恒, 张新旭, 肖湘^*. 深海微生物多样性. 生物多样性, 2013, 21:445-455.

授权专利：

1. 骆祝华, 胡杰鸽, 张新旭, 王志超, 凌铭煌, 高渊皓, 陈逍遥, 徐炜. 可降解聚氨酯类酵母真菌菌株及鉴定方法与用途. 国家发明专利, ZL202210403010.4.

2. 徐炜, 左啸天, 张新旭, 高渊皓, 骆祝华. 一种反硝化真菌及其应用. 国家发明专利, ZL202110374458.3.

3. 徐炜, 左啸天, 张新旭, 高渊皓, 骆祝华. 一株高效去除铵盐的海洋红酵母菌株WCBC及其应用. 国家发明专利, ZL202110911129.8.

4. 李升康, 张新旭, 张明, 张旭昇, 孙再桥. 一种准确计数无脊椎动物血淋巴中微生物的丰度的方法. 国家发明专利, ZL201711249372.8.

人才招聘：

本课题组长期招聘有微生物学、免疫学、生物信息学、水产养殖、分子生物学等研究背景的博士后与硕博研究生。