教育背景:
2015.09-2018.07 中国人民解放军军事科学院,公共卫生与预防医学,博士
2012.09-2015.07 山东农业大学,食品科学与工程,硕士
2008.09-2012.07 山东农业大学,食品科学与工程,学士
工作经历:
2024.04至今 深圳大学高等研究院 研究员、助理教授
2018.07-2024.03历任深圳大学高等研究院 博士后、副研究员
研究方向:
古菌功能演化与真核生物起源、蛋白功能演化
科研项目:
1. 国家自然科学基金委员会,面上项目,UEV-Vps23介导阿斯加德古菌ESCRT泛素化过程的分子机制研究,2024.01至2027.12,50万元,在研,主持
2. 国家自然科学基金委员会,青年科学基金项目,阿斯加德古菌ESCRT剪切膜结构的分子机制研究,2021.01至2023.12,24万元,结题,主持
3. 国家自然科学基金委员会,重大项目,古菌类真核生物内膜系统形成和蛋白的功能演化,2024.01至2028.12,365.84万元,在研,骨干(排名第二)
4. 广东省基础与应用基础研究基金,面上项目,基于延伸因子EF-1α的热稳定性探讨阿斯加德古菌温度适应性演化过程,2023.01至2025.12,10万元,在研,主持
5. 广东省基础与应用基础研究基金,青年基金,MK-D1古菌ESCRT的构建及其在真核细胞内膜系统起源模型的应用,2020.01至2022.12,10万元,结题,主持
6. 中国博士后科学基金,面上项目,基于Vps4功能探讨Asgard古菌ESCRT系统功能进化性,2019.01至2021.03,5万元,结题,主持
发表论文:
1. Zhongyi Lu#; Runyue Xia#; Siyu Zhang; Jie Pan; Yang Liu; Yuri I. Wolf; Eugene V. Koonin; Meng Li*; Evolution of optimal growth temperature in Asgard archaea inferred from the temperature dependence of GDP binding to EF-1A, Nature Communications, 2024, 1(515).
2. Zhongyi Lu#; Siyu Zhang#; Yang Liu#; Runyue Xia; Meng Li*; Origin of eukaryotic-like Vps23 shapes an ancient functional interplay between ESCRT and ubiquitin system in Asgard archaea, Cell Reports, 2024, 43(2).
3. Zhongyi Lu#; Ting Fu#; Tianyi Li; Yang Liu; Siyu Zhang; Jinquan Li; Junbiao Dai; Eugene V. Koonin; Guohui Li; Huiying Chu*; Meng Li*; Coevolution of Eukaryote-like Vps4 and ESCRT-III Subunits in the Asgard Archaea, mBio, 2020, 11(3): e00417-20.
4. Yunchun Yang#; Zhongyi Lu#; Mohammad Azari; Boran Kartal; Huan Du; Mingwei Cai; Graig W. Herbold; Xinghua Ding; Martin Denecke; Xiaoyan Li; Meng Li; Ji-Dong Gu*; Discovery of a new genus of anaerobic ammonium oxidizing bacteria with a mechanism for oxygen tolerance, Water Research, 2022, 226(3).(共同一作)
5. Zhongyi Lu#; Zongbao Liu; Cuijing Zhang; Qiaoyan Wei; Siyu Zhang; Meng Li*; Spatial and seasonal variations of sediment bacterial communities in a river-bay system in South China, Applied Microbiology and Biotechnology, 2021, 105(5): 1979-1989.
6. Zhongyi Lu#; Yong Chen#; Wei Chen#; Hui Liu; Qing Song; Xiaofeng Hu; Ziying Zou; Zhengxiang Liu; Libo Duo; Jiyong Yang; Yanwen Gong; Zhanke Wang; Xuqin Wu; Jingya Zhao; Changjian Zhang; Mengqiang Zhang; Li Han*; Characteristics of qacA/B-positive Staphylococcus aureus isolated from patients and a hospital environment in China, Journal of Antimicrobial Chemotherapy, 2015, 70(3): 653-657.
7. Zhongyi Lu#; Xiaodong Jia; Yong Chen; Xuelin Han; Fangyan Chen; Shuguang Tian; Xueting Su; Zongwei Li; Jingya Zhao; Xi Zhang; Mandong Hu; Liuyu Huang*; Li Han*; Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus, Antimicrobial Agents and Chemotherapy, 2018, 62(5): e01659-17.
8. Yong Chen#; Zhongyi Lu#; Jingjun Zhao; Ziying Zou; Yanwen Gong; Fen Qu; Zhiyao Bao; Guangbin Qiu; Mingsheng Song; Qing Zhang; Lin Liu; Mandong Hu; Xuelin Han; Shuguang Tian; Jingya Zhao; Fangyan Chen; Changjian Zhang; Yansong Sun; Paul E. Verweij; Liuyu Huang; Li Han*; Epidemiology and Molecular Characterizations of Azole Resistance in Clinical and Environmental Aspergillus fumigatus Isolates from China, Antimicrobial Agents and Chemotherapy, 2016, 60(10): 5878-5884. (共同一作)