On March 18, 2025, Prof. Xueji Zhang and Tailin Xu’s group published an article in the "NANO LETTERS" titled "An Integrated Janus Bioelectronic Bandage for Unidirectional Pumping and Monitoring of Wound Exudate". Professor Tailin Xu served as the corresponding author, Ph.D. candidate Jing Wang, undergraduate students Jintao Ye and Zhuoheng Li served as co-first authors, with Shenzhen University as the lead institution for publication.
Single-functional wound dressings provide limited therapeutic benefits for chronic wound healing. Effective care for chronic wounds requires a multifunction that integrates exudate management, therapeutic treatment, and continuous monitoring. This work introduced an integrated Janus bioelectronic wound care bandage designed to achieve self-pumping exudate management via an electrospinning Janus dressing with opposite wettability, antibacterial properties through silver nanoparticles (AgNPs), and the monitoring of multiplex biomarkers in wounds via electrochemical sensors positioned on the drainage side (Figure 1). The limits of detection (LOD) of sensors are 0.15 mM for glucose, 6.85 μM for UA, and 60.76 mV/decade for pH (4−8), respectively. We demonstrated in mice full-thickness wound models that this bandage effectively promoted wound healing, achieving a wound closure rate of 90.35% on day 14, which was 14.02% higher than that of conventional gauze. Additionally, the device monitored the dynamic changes of three biomarkers within wounds in situ over a period of 3 days.
This work was supported by Shenzhen Science and Technology Program (JCYJ20240813142503006), Shenzhen Overseas Talent Program, National Natural Science Foundation of China (22234006 and 224B2407), Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes (2024KSYS011), and Shenzhen Science and Technology Program (KQTD20221101093605019).
Original link: https://doi.org/10.1021/acs.nanolett.4c06147
Figure 1. The schematic and photographs of the Janus wound care bandage for exudate management and monitoring
