On June 3, 2025, Professor Zhou Ye was selected as a leading investigator for the 15th anniversary of the Royal Society of Chemistry's Chemical Science and was invited to publish a research paper titled "Unveiling the Switching Mechanism of Robust Tetrazine Based Memristive Nociceptors via a Spectroelectrochemical Approach" in the journal. This paper explores the use of organic small molecule materials for artificial nociceptors. JiYu Zhao, a joint doctoral student, is the first author, Xiaojun Peng, Ye Zhou, and Guanglong Ding are the corresponding authors.

Threshold-switching memristors exhibit significant potential for developing artificial nociceptors as their working principles and electrical characteristics closely mimic biological nociceptors. However, the development of high-performance artificial nociceptors is hindered by the randomness of conductive filament (CF) formation/rupture, caused by low-quality resistive switching (RS) films, and complex and uncontrollable RS mechanisms. Organic small-molecule materials are favored in electronic devices for their designability, low cost, easy synthesis, and high stability. In this study, we meticulously designed two D–π–A–π–D structured molecules, designated as TZ-1 and TZ-2, to serve as the RS layer in artificial nociceptors. By precisely modulating the electron-donating ability of the donor groups in these molecules, some key electrical properties of the memristor, such as the low SET voltage (0.42 V) and variation (0.055), high current ON/OFF ratio (∼106) and nanosecond level switching time (60 ns), can be successfully optimized. Moreover, a spectroelectrochemical strategy was employed for the first time to investigate the RS mechanism at the molecular level, elucidating the critical role of molecular design in modulating the device's working principles and electrical characteristics. The optimized memristor is capable of accurately emulating the four key behaviors of nociceptors. This achievement not only advances the application of organic materials in neuromorphic devices but also opens up new possibilities for the specialized customization of nociceptors.

This research was supported by grants from the National Natural Science Foundation of China (62304137), RSC Sustainable Laboratories Grant (L24-8215098370), the Guangdong Basic and Applied Basic Research Foundation (2023A1515012479, 2024B1515040002, 2024A1515011737 and 2025A1515011274), the Science and Technology Innovation Commission of Shenzhen (JCYJ20220818100206013), RSC Researcher Collaborations Grant (C23-2422436283), Ministry of Education of the People's Republic of China (202411080020), State Key Laboratory of Radio Frequency Heterogeneous Integration (Independent Scientific Research Program No. 2024010), the Hong Kong Research Grants Council, Young Collaborative Research Grant (C5001-24), Research Institute for Smart Energy (U-CDC9) and NTUT-SZU Joint Research Program.

Link：https://pubs.rsc.org/en/Content/ArticleLanding/2025/SC/D5SC02710A