报告题目：Transcriptional regulation of microalgae for concurrent lipid overproduction and secretion
主讲嘉宾：李宏业（暨南大学）
主持人：陈 峰 教授、高等研究院院长
时间：2019年11月14日周四15:00
地点：沧海校区致知楼（L4理工楼对面的原医学楼）725室  

报告摘要：

Commercialization of algal lipids and biofuels is still impractical owing to the unavailability of lipogenic strains and lack of economically viable oil extraction strategies. Because lipogenesis is governed by multiple factors, success in generating industrial-suitable algal strains using conventional strategies has been limited. We report the discovery of a novel bZIP1 transcription factor, NobZIP1, whose overexpression results in a remarkable elevation of lipid accumulation and lipid secretion in a model microalga Nannochloropsis oceanica, without impairing other physio-logical properties. Chromatin immunoprecipitation–quantitative PCR analysis revealed that the key genes up- and down-regulated by NobZIP1 are involved in lipogenesis and cell wall polymer synthesis, respectively, which, in turn, induce lipid overproduction and secretion. Among these regulated genes, UDP-glucose dehydrogenase was shown to alter cell wall composition, thus also boosting lipid secretion. In summary, these results offer a compre-hensive strategy for concurrent lipid overproduction and secretion, strongly increasing the commercial potential of microalgae.

嘉宾简介：

李宏业教授博士毕业于香港大学，2008年入职暨南大学，依托水生生物学国家重点学科，围绕海洋微藻的脂类生物活性物质开展代谢机理的系列研究，包括脂类合成途径解析、功能基因组学及基因表达调控、高附加值生物活性物质及生物毒素的合成机理、基于代谢工程及生物制造推动资源高值化利用。近5年作为通讯作者及第一单位，在Science子刊Science Advances、Metabolic Engineering、Environmental Microbiology、Biotechnology for Biofuels、Marine Biotechnology 等重要SCI期刊发表论文30余篇，其中SCI一区及二区期刊各12篇；获授权专利5件；多篇研究论文被 ScienceDirect 等评为高阅读量文章，并入选 ESI 高被引论文。主持成果获教育部高等学校科学研究优秀成果奖自然科学奖二等奖、广东省第四届南粤科技创新优秀学术论文一等奖等奖项。